Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid

oxycodone Oxycodone, sold under the brand name Roxicodone and OxyContin (which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain. It is highly addictive and is a commonly ...

with

paracetamol Paracetamol, or acetaminophen, is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Parac ...

(acetaminophen), used to treat moderate to severe

pain Pain is a distressing feeling often caused by intense or damaging Stimulus (physiology), stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sense, sensory and emotional experience associated with, or res ...

. In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6million prescriptions.

History

The United States

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...

(FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.

Society and culture

Percocet is often called perc for short. As of 2018, it was often name-dropped in rap music, such as

Future The future is the time after the past and present. Its arrival is considered inevitable due to the existence of time and the laws of physics. Due to the apparent nature of reality and the unavoidability of the future, everything that currently ex ...

's song " Mask Off".

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with

narcotic The term narcotic (, from ancient Greek ναρκῶ ''narkō'', "I make numb") originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiates ...

analgesics be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage. In December 2009, a study found a fivefold increase in oxycodone-related deaths in

Ontario, Canada Ontario is the southernmost Provinces and territories of Canada, province of Canada. Located in Central Canada, Ontario is the Population of Canada by province and territory, country's most populous province. As of the 2021 Canadian census, it ...

(mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.

References

{{DEFAULTSORT:Oxycodone Paracetamol Combination analgesics Hepatotoxins