Perazine (Taxilan) is a moderate-potency

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics m ...

of the

phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. ...

class. It is quite similar to

chlorpromazine Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar d ...

, and acts as a

dopamine antagonist A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and have been used in t ...

. It was very popular in West-Germany. A 2014

systematic review A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on ...

compared it with other antipsychotic drugs:

Synthesis

Phenothiazine-10-propionitrile 698-80-2(1) is treated with a mixture of acid and alcohol giving Methyl phenothiazinepropionate
CID:368244
(2). Heating with

1-methylpiperazine ''N''-Methylpiperazine is a heterocyclic organic compound. Uses ''N''-Methylpiperazine is a common building block used in organic synthesis. For example, ''N''-methylpiperazine is used in the manufacture of various pharmaceutical drugs includin ...

(3) gives the amide 1508-47-3(4). Reduction of this last by means of

diborane Diborane(6), commonly known as diborane, is the chemical compound with the formula . It is a highly toxic, colorless, and pyrophoric gas with a repulsively sweet odor. Given its simple formula, borane is a fundamental boron compound. It has att ...

yields ''Perazine'' (5).

References

External links

* Typical antipsychotics Phenothiazines 4-Methylpiperazin-1-yl compounds {{nervous-system-drug-stub

Synthesis

See also

References

External links