Paul B. Sigler ( –
/ref>) was the Henry Ford II Professor of Molecular

Biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

and

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

. Major awards included membership in the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

HHMI The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

Investigator status, and Guggenheim and

Helen Hay Whitney Helen Julia Hay Whitney (March 11, 1875 – September 24, 1944) was an American poet, writer, horse racing, racehorse owner and breeder, socialite, and philanthropist. She was a member by marriage of the prominent Whitney family of New York. Ea ...

Fellowships. He is noted for pioneering studies of

Phospholipase A2 The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycero ...

and

trp repressor Tryptophan repressor (or trp repressor) is a transcription factor involved in controlling amino acid metabolism. It has been best studied in ''Escherichia coli'', where it is a dimeric protein that regulates transcription of the 5 genes in the t ...

amongst many others.

Biography

Prior to coming to Yale, he was a professor at the

University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...

. He received his MD from

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

in 1959 and his undergraduate degree from

Princeton University Princeton University is a private university, private Ivy League research university in Princeton, New Jersey, United States. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial ...

in 1955. After briefly practicing medicine and working as a researcher for the

NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

, he would go on to earn a second doctorate, a PhD, from

Cambridge University The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

at the

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

working under David M. Blow before moving to the University of Chicago.

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of

. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. Yale also has sponsored Paul Sigler memorial symposia in the past. The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.

Death

Paul Sigler died on January 11, 2000, at

New Haven, Connecticut New Haven is a city of the U.S. state of Connecticut. It is located on New Haven Harbor on the northern shore of Long Island Sound. With a population of 135,081 as determined by the 2020 United States census, 2020 U.S. census, New Haven is List ...

, US, about a month before his 66th birthday.

Selected publications

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References

External links

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Paul B. Sigler on AcademicTree
{{DEFAULTSORT:Sigler, Paul B. Princeton University alumni American biophysicists 20th-century American biochemists Yale University faculty University of Chicago faculty Yale Department of Molecular Biophysics & Biochemistry faculty Scientists from New Haven, Connecticut Scientists from Chicago Scientists from New York City Scientists from Cambridge Scientists from Princeton, New Jersey Scientists from Washington, D.C. Scientists from Richmond, Virginia Members of the United States National Academy of Sciences Howard Hughes Medical Investigators 1934 births 2000 deaths Columbia University Vagelos College of Physicians and Surgeons alumni Alumni of the University of Cambridge Physicians from New Haven, Connecticut