Paul Oskar Morawitz (April 3, 1879 in

St. Petersburg Saint Petersburg, formerly known as Petrograd and later Leningrad, is the second-largest city in Russia after Moscow. It is situated on the River Neva, at the head of the Gulf of Finland on the Baltic Sea. The city had a population of 5,601, ...

– July 1, 1936) was a German

internist Internal medicine, also known as general medicine in Commonwealth nations, is a medical specialty for medical doctors focused on the prevention, diagnosis, and treatment of diseases in adults. Its namesake stems from "treatment of diseases of th ...

and

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...

whose most important work was in studying the

coagulation Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a thrombus, blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of co ...

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...

. After completing his medical studies at

Leipzig Leipzig (, ; ; Upper Saxon: ; ) is the most populous city in the States of Germany, German state of Saxony. The city has a population of 628,718 inhabitants as of 2023. It is the List of cities in Germany by population, eighth-largest city in Ge ...

(in 1901) he completed his army service, then joined Dr Ludolf von Krehl in

Tübingen Tübingen (; ) is a traditional college town, university city in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, and developed on both sides of the Neckar and Ammer (Neckar), Ammer rivers. about one in ...

as an assistant physician. Krehl inspired Morawitz in his studies of blood-related pathology. In 1907 he completed a dissertation on blood circulation (for his

Habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in Germany, France, Italy, Poland and some other European and non-English-speaking countries. The candidate fulfills a university's set criteria of excelle ...

), and he was appointed in the same year as chief clinician of the University clinic at

Freiburg im Breisgau Freiburg im Breisgau or simply Freiburg is the List of cities in Baden-Württemberg by population, fourth-largest city of the German state of Baden-Württemberg after Stuttgart, Mannheim and Karlsruhe. Its built-up area has a population of abou ...

. He progressed to become the ''Ordinarius'' and Director of the Medical inpatients at

Greifswald Greifswald (), officially the University and Hanseatic City of Greifswald (, Low German: ''Griepswoold'') is the fourth-largest city in the German state of Mecklenburg-Western Pomerania after Rostock, Schwerin and Neubrandenburg. In 2021 it surpa ...

in 1913, and in 1921 he took up a position in

Würzburg Würzburg (; Main-Franconian: ) is, after Nuremberg and Fürth, the Franconia#Towns and cities, third-largest city in Franconia located in the north of Bavaria. Würzburg is the administrative seat of the Regierungsbezirk Lower Franconia. It sp ...

. Finally, in 1926, he assumed the chair of Medicine in

. He died aged 57 of a

heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...

. Morawitz was a pioneer in the study of coagulation, and a 1905 landmark paper is still regarded as a springboard for further study of the physiology of blood; he perfected observations made earlier by Alexander Schmidt and described four coagulation factors:

fibrinogen Fibrinogen (coagulation factor I) is a glycoprotein protein complex, complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted Enzyme, enzymatically by thrombin to fibrin ...

(I),

prothrombin Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (, fibrose, thrombase, throm ...

(II), thrombokinase (III) and

calcium Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to it ...

(IV). He also pioneered

blood transfusion Blood transfusion is the process of transferring blood products into a person's Circulatory system, circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used ...

, initially without the benefit of

blood typing Blood compatibility testing is conducted in a medical laboratory to identify potential incompatibilities between Human blood group systems, blood group systems in blood transfusion. It is also used to diagnose and prevent some complications of pr ...

, and studied

angina Angina, also known as angina pectoris, is chest pain or pressure, usually caused by insufficient blood flow to the heart muscle (myocardium). It is most commonly a symptom of coronary artery disease. Angina is typically the result of parti ...

and the use of

quinidine Quinidine is a class I antiarrhythmic agent, class IA antiarrhythmic agent used to treat heart rhythm disturbances. It is a diastereomer of Antimalarial medication, antimalarial agent quinine, originally derived from the bark of the cinchona tre ...

as an

antiarrhythmic Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a class of drugs that are used to suppress abnormally fast rhythms (tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia. M ...

. He established a

blood bank A blood bank is a center where blood gathered as a result of blood donation is stored and preserved for later use in blood transfusion. The term "blood bank" typically refers to a department of a hospital usually within a clinical pathology labora ...

. He is commemorated by the annual "Paul Morawitz prize" by the '' Deutsche Gesellschaft für Kardiologie'' (German Cardiological Association).

References

External links

Resume von Prof. Dr. med. Paul Morawitz
at the

University of Leipzig Leipzig University (), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 December 1409 by Frederick I, Electo ...

{{DEFAULTSORT:Morawitz, Paul German hematologists German physiologists 1879 births 1936 deaths