Paul Lawrence Modrich (born June 13, 1946) is an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological che ...

, James B. Duke Professor of

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology ...

at Duke University and Investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, f ...

. He is known for his research on

DNA mismatch repair DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage. Mismatch ...

. Modrich received the

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

2015, jointly with

Aziz Sancar Aziz Sancar (born 8September 1946) is a Turkish molecular biologist specializing in DNA repair, cell cycle checkpoints, and circadian clock. In 2015, he was awarded the Nobel Prize in Chemistry along with Tomas Lindahl and Paul L. Modrich fo ...

and

Tomas Lindahl Tomas Robert Lindahl FRS FMedSci (born 28 January 1938) is a Swedish-British scientist specialising in cancer research. In 2015, he was awarded the Nobel Prize in Chemistry jointly with American chemist Paul L. Modrich and Turkish chemist Aziz ...

Early life and education

Modrich was born on June 13, 1946, in

Raton, New Mexico Raton ( ) is a city and the county seat of Colfax County in northeastern New Mexico. The city is located just south of Raton Pass. The city is also located about 6.5 miles south of the New Mexico–Colorado border and 85 miles west of Texas. Hi ...

to Laurence Modrich and Margaret McTurk. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at Raton High School where he graduated in 1964. Modrich is of

Croatian Croatian may refer to: * Croatia *Croatian language *Croatian people *Croatians (demonym) See also * * * Croatan (disambiguation) * Croatia (disambiguation) * Croatoan (disambiguation) * Hrvatski (disambiguation) * Hrvatsko (disambiguation) * S ...

, Montenegrin,

German German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Ger ...

and Scottish (Gaelic) origin. His paternal grandfather, of Croatian descent, is probably from the small village of Modrići near

Zadar Zadar ( , ; historically known as Zara (from Venetian and Italian: ); see also other names), is the oldest continuously inhabited Croatian city. It is situated on the Adriatic Sea, at the northwestern part of Ravni Kotari region. Zadar serv ...

, and grandmother of Montenegrin descent, both immigrated to the United States from coastal

Croatia , image_flag = Flag of Croatia.svg , image_coat = Coat of arms of Croatia.svg , anthem = "Lijepa naša domovino"("Our Beautiful Homeland") , image_map = , map_caption = , capit ...

in the late 19th century. His maternal family is of mixed German and Scotch-Irish descent. Modrich married fellow scientist Vickers Burdett in 1980. Modrich obtained a B.S. degree from the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private Land-grant university, land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern t ...

in 1968 and subsequently a Ph.D. degree from Stanford University in 1973. He continued his research as a postdoc in the lab of Charles C. Richardson at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools ...

for a year (1973–1974).

Research

Modrich became an assistant professor at the chemistry department of

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

in 1974. He joined Duke University's faculty in 1976 and has been a Howard Hughes Investigator since 1995. He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in ''E. coli''. They later searched for proteins associated with mismatch repair in humans.

Honors and awards

Honors and awards received by Modrich include: *1983: Pfizer Award in Enzyme Chemistry *1996: General Motors Charles S. Mott Prize in Cancer Research *1998: Robert J. and Claire Pasarow Foundation Medical Research Award for cancer research *2000 Feodor Lynen Medal *2005:

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more tha ...

Medal of Honor *2015: Nobel Prize in Chemistry *2016: Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences Modrich is a fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, ...

and a member of the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

and the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

References

External links

* {{DEFAULTSORT:Modrich, Paul L. 1946 births Nobel laureates in Chemistry Duke University faculty American people of Croatian descent American people of Montenegrin descent American people of German descent American people of Scotch-Irish descent Stanford University alumni American Nobel laureates American biochemists Howard Hughes Medical Investigators Living people Members of the United States National Academy of Sciences Fellows of the American Academy of Arts and Sciences People from Raton, New Mexico Articles containing video clips Members of the National Academy of Medicine