Sir Paul Gordon Fildes (10 February 1882 – 5 February 1971) was a British

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and

microbiologist A microbiologist (from Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of microscopic organisms such as bacteria, algae, fungi, and some types of par ...

who worked on the development of chemical-

biological weapon Biological agents, also known as biological weapons or bioweapons, are pathogens used as weapons. In addition to these living or replicating pathogens, toxins and Toxin#Biotoxins, biotoxins are also included among the bio-agents. More than 1,2 ...

ry at Porton Down during the

Second World War World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

.Fellow list of the Royal Society
/ref>

Biography

Early life

Fildes was born in

Kensington Kensington is an area of London in the Royal Borough of Kensington and Chelsea, around west of Central London. The district's commercial heart is Kensington High Street, running on an east–west axis. The north-east is taken up by Kensingt ...

London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...

, the son of the artist Sir

Luke Fildes Sir Samuel Luke Fildes (3 October 1843 – 28 February 1927) was a British painter and illustrator born in Liverpool and trained at the Royal College of Art, South Kensington and Royal Academy Schools. He was the grandson of the political act ...

and great grandson of reformist Mary Fildes, Paul attended

Winchester School Winchester College is an English public school (a long-established fee-charging boarding school for pupils aged 13–18) with some provision for day attendees, in Winchester, Hampshire, England. It was founded by William of Wykeham in 1382 as ...

and then studied surgery at

Trinity College, Cambridge Trinity College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any ...

, where he obtained an

MB BCh A Bachelor of Medicine, Bachelor of Surgery (; MBBS, also abbreviated as BM BS, MB ChB, MB BCh, or MB BChir) is a medical degree granted by medical schools or universities in countries that adhere to the United Kingdom's higher education tradi ...

degree.

Career

Fildes served as a lieutenant-commander in the

Royal Naval Volunteer Reserve Royal may refer to: People * Royal (name), a list of people with either the surname or given name * A member of a royal family or royalty Places United States * Royal, Arkansas, an unincorporated community * Royal, Illinois, a village * Roya ...

, stationed at the

Royal Naval Hospital Haslar The Royal Hospital Haslar in Gosport, Hampshire, which was also known as the Royal Naval Hospital Haslar, was one of Britain's leading Royal Naval Hospitals (and latterly a tri-service MOD hospital) for over 250 years. Built in the 1740s, it w ...

(1915–19) during the

First World War World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to ...

. In 1919 he was made an

Officer of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...

. After working at the

London Hospital The Royal London Hospital is a large teaching hospital in Whitechapel in the London Borough of Tower Hamlets. It is part of Barts Health NHS Trust. It provides district general hospital services for the City of London and London Borough of Tow ...

as an assistant bacteriologist, he moved in 1934 to work at the

Middlesex Hospital Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally clos ...

. He was also elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

in 1934. In 1940 he helped Donald D. Woods discover how sulphonamides worked. He was a member of the scientific staff, Medical Research Council (1934–49).

World War II

Fildes asserted that he assisted with Operation Anthropoid the assassination of top Nazi

Reinhard Heydrich Reinhard Tristan Eugen Heydrich ( , ; 7 March 1904 – 4 June 1942) was a German high-ranking SS and police official during the Nazi era and a principal architect of the Holocaust. He held the rank of SS-. Many historians regard Heydrich ...

in Prague by providing the

Czech Czech may refer to: * Anything from or related to the Czech Republic, a country in Europe ** Czech language ** Czechs, the people of the area ** Czech culture ** Czech cuisine * One of three mythical brothers, Lech, Czech, and Rus *Czech (surnam ...

agents of the

Special Operations Executive Special Operations Executive (SOE) was a British organisation formed in 1940 to conduct espionage, sabotage and reconnaissance in German-occupied Europe and to aid local Resistance during World War II, resistance movements during World War II. ...

with modified No. 73 Grenades filled with botulin toxin. The story has been met with scepticism, given the absence of any indication that Heydrich displayed any of the highly distinctive symptoms of

botulism Botulism is a rare and potentially fatal illness caused by botulinum toxin, which is produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, Fatigue (medical), feeling tired, and trouble speaking. ...

. In 1940 Fildes was put in charge of a newly created department, the Biology Department, Porton (BDP) at Porton Down to study the defensive implications of a bacterial attack and there built up a team of microbiologists to study the use of biological weapons, including anthrax and botulinum toxin. An early project was the creation of a stockpile of a million anthrax impregnated cattle cakes to be used in a possible retaliatory attack. In 1942 it famously carried out tests of an anthrax bio-weapon developed at Porton Down at Gruinard Island. He also assisted with the

anthrax Anthrax is an infection caused by the bacterium '' Bacillus anthracis'' or ''Bacillus cereus'' biovar ''anthracis''. Infection typically occurs by contact with the skin, inhalation, or intestinal absorption. Symptom onset occurs between one ...

strain tests on Gruinard Island, performing necropsies on the bodies of anthrax-exposed sheep, to determine if they had died as a direct result of anthrax poisoning. This work produced the world's first working anthrax bomb in the summer of 1942. At the end of the war he returned to university life and handed over control of the department to his deputy David Henderson, who oversaw the building of a new purpose designed laboratory facility and the creation of the autonomous Microbiological Research Department. He was knighted in the 1946 New Year Honours.

Later years

After the war Fildes worked at the

Sir William Dunn School of Pathology The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergr ...

in Oxford, headed by Nobel Prize winner Sir

Howard Florey Howard Walter Florey, Baron Florey, (; 24 September 1898 – 21 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Ernst Chain and Sir Alexander Fleming for his ro ...

, to study on the biochemistry of bacteriophage T1 (and to a lesser extent, T2) multiplication. Fildes received the

Copley Medal The Copley Medal is the most prestigious award of the Royal Society of the United Kingdom, conferred "for sustained, outstanding achievements in any field of science". The award alternates between the physical sciences or mathematics and the bio ...

in 1963 from the Royal Society.

Works

He was the author of works on

haemophilia Haemophilia (British English), or hemophilia (American English) (), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a long ...

and

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...

References

{{DEFAULTSORT:Fildes, Paul 1882 births 1971 deaths People educated at Winchester College Alumni of Trinity College, Cambridge British microbiologists Fellows of the Royal Society Recipients of the Copley Medal Royal Naval Volunteer Reserve personnel of World War II Knights Bachelor Royal Medal winners Place of birth missing Officers of the Order of the British Empire