The anterior pituitary (also called the adenohypophysis or pars anterior) is a major

organ Organ and organs may refer to: Biology * Organ (biology), a group of tissues organized to serve a common function * Organ system, a collection of organs that function together to carry out specific functions within the body. Musical instruments ...

of the

endocrine system The endocrine system is a messenger system in an organism comprising feedback loops of hormones that are released by internal glands directly into the circulatory system and that target and regulate distant Organ (biology), organs. In vertebrat ...

. The anterior pituitary is the glandular, anterior lobe that together with the

posterior pituitary The posterior pituitary (or neurohypophysis) is the posterior lobe of the pituitary gland which is part of the endocrine system. Unlike the anterior pituitary, the posterior pituitary is not glandular, but largely a collection of axonal projec ...

(or neurohypophysis) makes up the

pituitary gland The pituitary gland or hypophysis is an endocrine gland in vertebrates. In humans, the pituitary gland is located at the base of the human brain, brain, protruding off the bottom of the hypothalamus. The pituitary gland and the hypothalamus contr ...

(hypophysis) which, in

human Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing ...

s, is located at the base of the

brain The brain is an organ (biology), organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head (cephalization), usually near organs for ...

, protruding off the bottom of the

hypothalamus The hypothalamus (: hypothalami; ) is a small part of the vertebrate brain that contains a number of nucleus (neuroanatomy), nuclei with a variety of functions. One of the most important functions is to link the nervous system to the endocrin ...

. The anterior pituitary regulates several

physiological Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...

processes, including stress, growth,

reproduction Reproduction (or procreation or breeding) is the biological process by which new individual organisms – "offspring" – are produced from their "parent" or parents. There are two forms of reproduction: Asexual reproduction, asexual and Sexual ...

, and

lactation Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The process ...

. Proper functioning of the anterior pituitary and of the organs it regulates can often be ascertained via

blood test A blood test is a medical laboratory, laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick. Multiple tests for specific blood components, such as a glucose ...

s that measure

hormone A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physio ...

levels.

Structure

The

sits in a protective bony enclosure called the sella turcica (''Turkish chair/saddle''). It is composed of three lobes: the anterior, intermediate, and posterior lobes. In many animals, these lobes are distinct. However, in humans, the intermediate lobe is but a few cell layers thick and indistinct; as a result, it is often considered part of the anterior pituitary. In all animals, the fleshy, glandular anterior pituitary is distinct from the neural composition of the pars nervosa of the

. The anterior pituitary is composed of three regions, the pars distalis, pars tuberalis, and pars intermedia.

Pars distalis

The pars distalis (distal part) comprises the majority of the anterior pituitary and is where the bulk of pituitary hormone production occurs. The pars distalis contains two types of cells, including chromophobe cells and chromophil cells. The chromophils can be further divided into acidophils (alpha cells) and basophils (beta cells). These cells all together produce hormones of the anterior pituitary and release them into the blood stream. Nota bene: The terms "basophil" and "acidophil" are used by some books, whereas others prefer not to use these terms. This is due to the possible confusion with white blood cells, where one may also find basophils and acidophils. File:Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated.jpg, Microanatomy of the pars distalis showing chromophobes, basophils, and acidophils File:Histology of anterior pituitary eosinophilic follicles.jpg, Eosinophilic follicles are a common normal finding in the anterior pituitary.

Pars tuberalis

The pars tuberalis (tubular part) forms a part of a highly vascularised sheath extending up from the pars distalis, which joins with the

pituitary stalk The pituitary stalk, also known as the infundibular stalk, infundibulum, or Fenderson's funnel, is the connection between the hypothalamus and the posterior pituitary, the posterior lobe of the pituitary gland. The floor of the third ventricle is ...

(also known as the infundibular stalk or infundibulum), arising from the posterior lobe. (The pituitary stalk connects the hypothalamus to the posterior pituitary.) The function of the pars tuberalis is poorly understood. However, it has been seen to be important in receiving the endocrine signal in the form of TSHB (a β subunit of TSH), informing the pars tuberalis of the photoperiod (length of day). The expression of this subunit is regulated by the secretion of

melatonin Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cow ...

in response to light information transmitted to the

pineal gland The pineal gland (also known as the pineal body or epiphysis cerebri) is a small endocrine gland in the brain of most vertebrates. It produces melatonin, a serotonin-derived hormone, which modulates sleep, sleep patterns following the diurnal c ...

. Earlier studies have shown localization of melatonin receptors in this region. Principal cells of the pars tuberalis are low columnar in form, with the cytoplasm containing numerous lipid droplets, glycogen granules, and occasional colloid droplets. A sparse population of functional gonadotrophs are present (indicated by immunoreactivity for ACTH, FSH, and LH).

Pars intermedia

The pars intermedia (intermediate part) sits between the pars distalis and the posterior pituitary, forming the boundary between the anterior and posterior pituitaries. It is very small and indistinct in humans.

Development

The anterior pituitary is derived from the

ectoderm The ectoderm is one of the three primary germ layers formed in early embryonic development. It is the outermost layer, and is superficial to the mesoderm (the middle layer) and endoderm (the innermost layer). It emerges and originates from the o ...

, more specifically from that of

Rathke's pouch In embryogenesis, Rathke's pouch is an evagination at the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary (adenohypophysis), a part of the endocrine system. Development Rathke's pou ...

, part of the developing

hard palate The hard palate is a thin horizontal bony plate made up of two bones of the facial skeleton, located in the roof of the mouth. The bones are the palatine process of the maxilla and the horizontal plate of palatine bone. The hard palate spans ...

in the embryo. Rathke's pouch is also

ectodermal The ectoderm is one of the three primary germ layers formed in early embryonic development. It is the outermost layer, and is superficial to the mesoderm (the middle layer) and endoderm (the innermost layer). It emerges and originates from the o ...

in origin. The pouch eventually loses its connection with the

pharynx The pharynx (: pharynges) is the part of the throat behind the human mouth, mouth and nasal cavity, and above the esophagus and trachea (the tubes going down to the stomach and the lungs respectively). It is found in vertebrates and invertebrates ...

, giving rise to the anterior pituitary. The anterior wall of Rathke's pouch proliferates, filling most of the pouch to form the pars distalis and the pars tuberalis. The posterior wall of the anterior pituitary forms the pars intermedia. Its formation from the soft tissues of the upper palate contrasts with the posterior pituitary, which originates from

neuroectoderm Neuroectoderm (or neural ectoderm or neural tube epithelium) consists of cells derived from the ectoderm. Formation of the neuroectoderm is the first step in the development of the nervous system. The neuroectoderm receives bone morphogenetic pro ...

.Nelson, R. J. (2011) An Introduction to Behavioral Endocrinology, 4th Edition. Sunderland, MA: Sinauer Associates, Inc.

Function

The anterior pituitary contains five types of endocrine cell, and they are defined by the hormones they secrete: somatotropes (GH); lactotropes (PRL); gonadotropes (LH and FSH); corticotropes (ACTH) and thyrotropes (TSH). It also contains non-endocrine folliculostellate cells which are thought to stimulate and support the endocrine cell populations. Hormones secreted by the anterior pituitary are trophic hormones (Greek: trophe, "nourishment"). Trophic hormones directly affect growth either as hyperplasia or hypertrophy on the tissue it is stimulating. Tropic hormones are named for their ability to act directly on target tissues or other

endocrine gland The endocrine system is a network of glands and organs located throughout the body. Along with the nervous system, it makes the neuroendocrine system, which controls and regulates many of the body's functions. Endocrine glands are ductless gland ...

s to release hormones, causing numerous cascading physiological responses.

Role in the endocrine system

Hypothalamic control

Hormone secretion from the anterior pituitary gland is regulated by hormones secreted by the

Neuroendocrine cells Neuroendocrine cells are cells that receive neuronal input (through neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release messenger molecules (hormones) into the blood. In this way they bri ...

in the hypothalamus project

axons An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see spelling differences) is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action pot ...

to the

median eminence The median eminence is generally defined as the portion of the ventral hypothalamus from which the portal vessels arise. The median eminence is a small swelling on the tuber cinereum, posterior to and on top of the pituitary stalk; it lies in th ...

, at the base of the brain. At this site, these cells can release substances into small blood vessels that travel directly to the anterior pituitary gland (the hypothalamo-hypophyseal portal vessels).

Other mechanisms

Aside from hypothalamic control of the anterior pituitary, other systems in the body have been shown to regulate the anterior pituitary's function.

GABA GABA (gamma-aminobutyric acid, γ-aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system. GA ...

can either stimulate or inhibit the secretion of

luteinizing hormone Luteinizing hormone (LH, also known as luteinising hormone, lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland. The production of LH is regulated by gonadotropin-releasing hormone (G ...

(LH) and

growth hormone Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in ...

(GH) and can stimulate the secretion of thyroid-stimulating hormone (TSH).

Prostaglandin Prostaglandins (PG) are a group of physiology, physiologically active lipid compounds called eicosanoids that have diverse hormone-like effects in animals. Prostaglandins have been found in almost every Tissue (biology), tissue in humans and ot ...

s are now known to inhibit

adrenocorticotropic hormone Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important ...

(ACTH) and also to stimulate TSH, GH and LH release. Clinical evidence supports the experimental findings of the excitatory and inhibitory effects GABA has on GH secretion, dependent on GABA's site of action within the hypothalamic-pituitary axis.

Effects of the anterior pituitary

:;Thermal homeostasis The homeostatic maintenance of the anterior pituitary is crucial to our physiological well being. Increased plasma levels of TSH induce

hyperthermia Hyperthermia, also known as overheating, is a condition in which an individual's body temperature is elevated beyond normal due to failed thermoregulation. The person's body produces or absorbs more heat than it dissipates. When extreme te ...

through a mechanism involving increased

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

and

cutaneous Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different d ...

vasodilation Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel wa ...

. Increased levels of LH also result in

hypothermia Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe ...

but through a decreased metabolism action. ACTH increase metabolism and induce cutaneous vasoconstriction, increased plasma levels also result in

and

prolactin Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk. It is influential in over 300 separate processes in various vertebrates, including humans. Prolactin is secr ...

decreases with decreasing temperature values.

follicle-stimulating hormone Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone. FSH is synthesized and secreted by the gonadotropic cells of the anterior pituitary gland and regulates the development, growth, puberty, pubertal maturat ...

(FSH) also may cause

if increased beyond homeostatic levels through an increased metabolic mechanism only. :;Gonadal function

Gonadotrope 1. Introduction Gonadotropic cells (also known as gonadotropes, gonadotrophs, delta cells, or delta basophils) are endocrine cells in the anterior pituitary that produce gonadotropins. More specifically, gonadotrophs produce and secrete glyco ...

s, primarily luteinising hormone (LH) secreted from the anterior pituitary stimulates the ovulation cycle in female

mammal A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...

s, whilst in the males, LH stimulates the synthesis of

androgen An androgen (from Greek ''andr-'', the stem of the word meaning ) is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes ...

which drives the ongoing will to mate together with a constant production of

sperm Sperm (: sperm or sperms) is the male reproductive Cell (biology), cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm ...

. :;HPA axis Main article '' Hypothalamic-pituitary-adrenal axis'' The anterior pituitary plays a role in stress response.

Corticotropin releasing hormone Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress (biology), stress responses. It is a releasin ...

(CRH) from the hypothalamus stimulates ACTH release in a cascading effect that ends with the production of glucocorticoids from the

adrenal cortex The adrenal cortex is the outer region and also the largest part of the adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. I ...

Behavioral effects

:;Development: The release of GH, LH, and FSH are required for correct human development, including gonadal development. :;Breast-feeding: Release of the hormone

is essential for

. :;Stress: Operating through the hypothalamic-pituitary-adrenal axis (HPA), the anterior pituitary gland has a large role in the neuroendocrine system's stress response. Stress induces a release of

corticotropin-releasing hormone Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses. It is a releasing hormone that b ...

(CRH) and

vasopressin Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the ''AVP'' gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It ...

from the

, which activates the release of

(ACTH) from the anterior pituitary gland. Then, this acts on the

to produce glucocorticoids such as

cortisol Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. When used as medication, it is known as hydrocortisone. Cortisol is produced in many animals, mainly by the ''zona fasciculata'' of the adrenal corte ...

. These glucocorticoids act back on the anterior pituitary gland and the

with

negative feedback Negative feedback (or balancing feedback) occurs when some function (Mathematics), function of the output of a system, process, or mechanism is feedback, fed back in a manner that tends to reduce the fluctuations in the output, whether caused ...

to slow the production of CRH and ACTH. Increased

under stress conditions can cause the following: metabolic effects (mobilization of

glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...

, fatty acids, and

amino acids Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the Proteinogenic amino acid, 22 α-amino acids incorporated into p ...

), bone re-absorption (calcium mobilization), activation of the

sympathetic nervous system The sympathetic nervous system (SNS or SANS, sympathetic autonomic nervous system, to differentiate it from the somatic nervous system) is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous sy ...

response (fight or flight), anti-inflammatory effects, and inhibition of reproduction/growth. When the anterior pituitary gland is removed ( hypophysectomy) in rats, their avoidance learning mechanisms were slowed, but injections of ACTH restored their performance. In addition, stress may delay the release of reproductive hormones such as

(LH) and

(FSH). This shows that the anterior pituitary gland is involved in behavioral functions as well as being part of a larger pathway for stress responses. It is also known that (HPA) hormones are related to certain skin diseases and skin homeostasis. There is evidence linking hyperactivity of HPA hormones to stress-related skin diseases and skin tumors. :;Aging: Operating through the hypothalamic-pituitary-gonadal axis, the anterior pituitary gland also affects the

reproductive system The reproductive system of an organism, also known as the genital system, is the biological system made up of all the anatomical organs involved in sexual reproduction. Many non-living substances such as fluids, hormones, and pheromones are al ...

. The hypothalamus releases

gonadotropin-releasing hormone Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and rele ...

(GnRH), which stimulates the release of

(LH) and

. Then the

gonads A gonad, sex gland, or reproductive gland is a mixed gland and sex organ that produces the gametes and sex hormones of an organism. Female reproductive cells are egg cells, and male reproductive cells are sperm. The male gonad, the testicle, ...

produce

estrogen Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three ...

and

testosterone Testosterone is the primary male sex hormone and androgen in Male, males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testicles and prostate, as well as promoting se ...

. The decrease in release of gonadotropins (LH and FSH) caused by normal aging may be responsible for

impotence Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a Human penis, penile erection with sufficient rigidity and durat ...

and frailty in elderly men because of the eventual decrease in production of testosterone. This lower level of

can have other effects, such as reduced

libido In psychology, libido (; ) is psychic drive or energy, usually conceived of as sexual in nature, but sometimes conceived of as including other forms of desire. The term ''libido'' was originally developed by Sigmund Freud, the pioneering origin ...

, well-being and mood, muscle and bone strength, and metabolism. :;Tactile responding: It has been shown that infant mice who were stroked with a paintbrush (simulating motherly care) had more release and binding of

(GH) from the anterior pituitary gland. :;Circadian rhythms: Light information received by the eyes is transmitted to the

via the circadian pacemaker (the

suprachiasmatic nucleus The suprachiasmatic nucleus or nuclei (SCN) is a small region of the brain in the hypothalamus, situated directly above the optic chiasm. It is responsible for regulating sleep cycles in animals. Reception of light inputs from photosensitive r ...

). Diminishing light stimulates the release of

from the pineal gland which can also affect the secretion levels in the hypothalamic-pituitary-gonadal axis. Melatonin can lower levels of LH and FSH, which will decrease levels of

and testosterone. In addition, melatonin may affect production of

Clinical significance

Increased activity

Hyperpituitarism Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; it typically results from a pituitary adenoma. In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecr ...

is the condition where the pituitary secretes excessive amounts of hormones. This hypersecretion often results in the formation of a

pituitary adenoma Pituitary adenomas are tumors that occur in the pituitary gland. Most pituitary tumors are benign, approximately 35% are invasive and just 0.1% to 0.2% are carcinomas.acromegaly Acromegaly is a disorder that results in excess growth of certain parts of the human body. It is caused by excess growth hormone (GH) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. There ...

results from excessive secretion of growth hormone (GH) often being released by a pituitary adenoma. This disorder can cause disfigurement and possibly death and can lead to

gigantism Gigantism (, ''gígas'', "wiktionary:giant, giant", plural γίγαντες, ''gígantes''), also known as giantism, is a condition characterized by excessive growth and height significantly above average height, average. In humans, this conditi ...

, a hormone disorder shown in "giants" such as André the Giant, where it occurs before the epiphyseal plates in bones close in puberty. The most common type of pituitary tumour is a

prolactinoma A prolactinoma is a tumor (adenoma) of the pituitary gland that produces the hormone prolactin. It is the most common type of functioning pituitary tumor. Symptoms of prolactinoma are due to abnormally high levels of prolactin in the blood ( hyp ...

which hypersecretes

. A third type of pituitary adenoma secretes excess ACTH, which in turn, causes an excess of

to be secreted and is the cause of

Cushing's disease Cushing's disease is one cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (spec ...

Decreased activity

Hypopituitarism is characterized by a decreased secretion of hormones released by the anterior pituitary. For example, hypo-secretion of GH prior to puberty can be a cause of

dwarfism Dwarfism is a condition of people and animals marked by unusually small size or short stature. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dwarfism is . '' ...

. In addition, secondary adrenal insufficiency can be caused by hypo-secretion of ACTH which, in turn, does not signal the adrenal cortex to produce a sufficient amount of

. This is a life-threatening condition. Hypopituitarism could be caused by the destruction or removal of the anterior pituitary tissue through traumatic brain injury, tumor,

tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...

, or

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...

, among other causes. This disorder used to be referred to as

Simmonds' disease Sheehan's syndrome, also known as postpartum pituitary gland necrosis, occurs when the pituitary gland is damaged due to significant blood loss and hypovolemic shock (ischemic necrosis) or stroke, originally described during or after childbirth le ...

but now according to the Diseases Database it is called Sheehan syndrome. If the hypopituitarism is caused by the blood loss associated with childbirth, the disorder is referred to as Sheehan syndrome.

History

Etymology

The anterior pituitary is also known as the adenohypophysis, meaning "glandular undergrowth", from the

Greek Greek may refer to: Anything of, from, or related to Greece, a country in Southern Europe: *Greeks, an ethnic group *Greek language, a branch of the Indo-European language family **Proto-Greek language, the assumed last common ancestor of all kno ...

''adeno-'' ("gland"), ''hypo'' ("under"), and ''physis'' ("growth").

Additional images

Image:Gray1180.png, The anterior pituitary is the anterior,

gland A gland is a Cell (biology), cell or an Organ (biology), organ in an animal's body that produces and secretes different substances that the organism needs, either into the bloodstream or into a body cavity or outer surface. A gland may also funct ...

ular lobe of the

. Image:Nasennebenhöhlen.gif Image:Gray1181.png, Gland shown in monkey

References

External links

*
Embryology at unc.edu

The Pituitary Network Association -- www.pituitary.org

Secretion of hormones from the Anterior Pituitary Gland
{{Authority control Endocrine system anatomy Human head and neck

Structure

Pars distalis

Pars tuberalis

Pars intermedia

Development

Function

Role in the endocrine system

Hypothalamic control

Other mechanisms

Effects of the anterior pituitary

Behavioral effects

Clinical significance

Increased activity

Decreased activity

History

Etymology

Additional images

See also

References

Further reading

External links