Papuamides A and B are
depsipeptides which appear to protect
T cells
T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their ce ...
from
HIV
The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the im ...
.
They were isolated from the
sponge
Sponges or sea sponges are primarily marine invertebrates of the animal phylum Porifera (; meaning 'pore bearer'), a basal clade and a sister taxon of the diploblasts. They are sessile filter feeders that are bound to the seabed, and a ...
Theonella,
and are part of a larger group of structurally similar depsipeptides—also isolated from sponges—including
neamphamide A
Neamphamide A is an HIV-inhibitory isolate of the sea sponge '' Neamphius huxleyi''.
References
Depsipeptides
{{organic-compound-stub ...
,
callipeltin A, and
mirabamides A-D.
References
Depsipeptides
{{organic-compound-stub