Pamiparib, sold under the brand name Partruvix, is a pharmaceutical drug used for the treatment of various types of cancer.
Pamiparib is a member of the
PARP inhibitor
PARP inhibitors are a class of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells.
Medical uses of these drugs include the treatment of heri ...
drug class.
[
In China, it is approved for the treatment of germline ]BRCA mutation
A ''BRCA'' mutation is a mutation in either of the ''BRCA1'' and ''BRCA2'' genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, ...
-associated recurrent advanced ovarian
The ovary () is a gonad in the female reproductive system that produces ova; when released, an ovum travels through the fallopian tube/oviduct into the uterus. There is an ovary on the left and the right side of the body. The ovaries are endoc ...
, fallopian tube
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (: salpinx), are paired tubular sex organs in the human female body that stretch from the Ovary, ovaries to the uterus. The fallopian tubes are part of the female reproduct ...
, and primary peritoneal cancer
Primary peritoneal cancer or carcinoma is also known as serous surface papillary carcinoma, primary peritoneal carcinoma, extra-ovarian serous carcinoma, primary serous papillary carcinoma, and psammomacarcinoma. It was historically classified und ...
s previously treated with two or more lines of chemotherapy.
It is currently under investigation for the treatment of other forms of cancer.
References
PARP inhibitors
Heterocyclic compounds with 5 rings
Nitrogen heterocycles
Fluoroarenes
Carboxamides
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