Paeoniflorin is a chemical compound which is one of the major constituents of an herbal medicine derived from ''
Paeonia lactiflora''. It can also be isolated from the fresh water fern ''
Salvinia molesta''.
In ''Paeonia'', it can form new compounds with addition of phenolic substituents. In a study in female rats, paeoniflorin was found to inhibit the production of
testosterone
Testosterone is the primary male sex hormone and androgen in Male, males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testicles and prostate, as well as promoting se ...
within the ovaries, however does not significantly affect the production of
estradiol
Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is responsible ...
.
In mice, paeoniflorin was shown to protect against neuroinflammation and depression-like behavior induced by
FN alpha.
[Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice.]
References
Glucosides
Benzoate esters
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