Renal tissue kallikrein (, ''glandular kallikrein'', ''pancreatic kallikrein'', ''submandibular kallikrein'', ''submaxillary kallikrein'', ''kidney kallikrein'', ''urinary kallikrein'', ''

kallikrein Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by ''KLKB1 gene'') has no known paralogue, while tissue kallikrein-related peptidases (''KLKs'') encode a f ...

'', ''salivary kallikrein'', ''kininogenin'', ''kininogenase'', ''callicrein'', ''glumorin'', ''padreatin'', ''padutin'', ''kallidinogenase'', ''bradykininogenase'', ''depot-padutin'', ''urokallikrein'', ''dilminal D'', ''onokrein P'') is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

. Renal tissue

is formed from

kidney In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organ (anatomy), organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and rig ...

tissue prokallikrein by activation with the enzyme

trypsin Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the dig ...

. It catalyses the

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

causing preferential cleavage of Arg- bonds in small molecule substrates, acting to highly selectively release

kallidin Kallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin by the aminopeptidase enzyme. Effects of Kinins K ...

(lysyl-bradykinin, a bioactive

kinin A kinin is any of various structurally related peptides, such as bradykinin and kallidin. They are members of the autacoid family. Kinins are peptides that are cleaved from kininogens by the process of kallikreins. Kallikreins activate kinins ...

) from

kininogen Kininogens are Protein precursor, precursor proteins for Kinin, kinins, biologically active Peptide, polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, Inflammation, inflammatory regulation, and the regulation of t ...

(a kinin protein precursor).

References

External links

* {{Portal bar, Biology, border=no EC 3.4.21