Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the ''PTPN21'' gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Interactions

PTPN21 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

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and

KIF1C Kinesin-like protein KIF1C is a protein that in humans is encoded by the ''KIF1C'' gene. Kif1C is a fast, plus-end directed microtubule motor. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse wit ...

Function

Interactions

References

Further reading