PSB-SB-1202 is a

coumarin Coumarin () or 2''H''-chromen-2-one is an aromatic organic chemical compound with formula . Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by an unsaturated lactone ring , forming a second six-me ...

derivative which is an agonist at the cannabinoid receptors CB₁ and CB₂, with a CB₁ Ki of 32nM and a CB₂ Ki of 49nM. It is also a weak antagonist at the related receptor

GPR55 G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the ''GPR55'' gene. GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors. History GPR55 was ide ...

, with an IC₅₀ of 6350nM, but has no significant affinity for

GPR18 ''N''-Arachidonyl glycine receptor (NAGly receptor), also known as G protein-coupled receptor 18 (GPR18), is a protein that in humans is encoded by the ''GPR18'' gene. Along with the other previously orphan receptors GPR55 and GPR119, GPR18 has b ...

References

{{Cannabinoids Cannabinoids Coumarins

See also

References