PPP2CA
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that (in humans) is encoded by the ''PPP2CA''
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.


Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.


Interactions

PPP2CA has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with: *
Bcl-2 Bcl-2, encoded in humans by the ''BCL2'' gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first a ...
, * Bestrophin 1, * CCNG2, *
CTTNBP2NL CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the ''CTTNBP2NL'' gene. It is a substrate for phosphorylation. Interactions CTTNBP2NL has been shown to interact with: * FAM40A, and * MOBKL3, * PDCD10, * PPP2CA, ...
, *
CTTNBP2 Cortactin-binding protein 2 is a protein that in humans is encoded by the ''CTTNBP2'' gene. Function This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulat ...
, *
Cyclin-dependent kinase 2 Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein ...
, *
Cyclin-dependent kinase 6 Cell division protein kinase 6 (CDK6) is an enzyme encoded by the ''CDK6'' gene. It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein encoded by this gene is a member of th ...
, *
FAM40A Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the ''FAM40A'' gene. Characteristics and secondary structure FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 Dalton (unit), daltons. ...
, *
IGBP1 Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the ''IGBP1'' gene. Function The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific ...
, *
MOBKL3 Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the ''MOBKL3'' gene. Function This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expr ...
, *
PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the ''PPP2R1A'' gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490). Functi ...
, *
PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the ''PPP2R1B'' gene. Function This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosph ...
, *
PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the ''PPP2R2A'' gene. Function The product of this gene belongs to the phosphatase 2 regulatory subunit B fa ...
, *
PPP2R3B Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the ''PPP2R3B'' gene. Function Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases ...
, *
PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the ''PPP2R5A'' gene. Function The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Prote ...
, * PPP2R5B, * PPP2R5C, *
PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the ''PPP2R5D'' gene. Mutations in ''PPP2R5D'' cause Jordan's syndrome. Function The product of this gene belongs to the ...
, * PPP2R5E, *
STRN3 Striatin-3 is a protein that in humans is encoded by the ''STRN3'' gene. Interactions STRN3 has been shown to interact with: * CTTNBP2NL, * CTTNBP2, * FAM40A, * MOBKL3, * PDCD10, * PPP2CA, * PPP2R1A, * RP6-213H19.1, * STK24, and * ...
, *
STRN Striatin is a protein that in humans is encoded by the ''STRN'' gene. Interactions STRN has been shown to interact with: * CTTNBP2NL, * CTTNBP2, * FAM40A, * MOBKL3, * PDCD10, * PPP2CA, * PPP2R1A, * RP6-213H19.1, * STK24, * S ...
, and *
TLX1 T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the ''TLX1'' gene, which was initially named ''HOX11''. Interactions TLX1 has been shown to Protein-protein interaction, interact with PPP1CC, PPP2CB and PPP2CA. ...
.


See also

*
PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the ''PPP2CB'' gene. Function This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four m ...


References


Further reading

* * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=5515