POU domain class 2-associating factor 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''POU2AF1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
The protein is also termed
Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.
[https://www.ncbi.nlm.nih.gov/gene?term=(ocab ene%20AND%20(Homo%20sapiens rgn%20AND%20alive rop20NOT%20newentry enesort=weight ] BOB1 is a
transcriptional coactivator
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA p ...
(i.e. a protein that controls the activity of
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s) which is expressed principally by
B-cell lymphocytes and controls
immunoglobulin
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
and other genes critical for these cells expression of
CD20,
CRISP-3, and
CD36.
The expression of BOB1 has proven useful for identifying certain
lymphoma
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). In current usage the name usually refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enl ...
s as being B-cell lymphomas,
as exemplified in studies which use BAB1 expression to help identify lymphomas as being
diffuse large B-cell lymphomas, not otherwise specified.
Interactions
POU2AF1 has been shown to
interact with:
*
POU2F1 and
*
SIAH1.
See also
*
POU domain
* POU domain class 2 transcription factors:
**
POU2F1,
POU2F2
POU or pou may refer to:
People
* Pou (surname), a surname
* Chu Pou (303–350), Chinese general and politician
* Pou Temara (born 1948), New Zealand Māori academic
Codes
* POU, IATA airport code and FAA location identifier for Hudson Valley Re ...
,
POU2F3
POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the ''POU2F3'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meanin ...
References
Further reading
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