Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the ''POLDIP2''
gene in humans.
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).
POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus and the mitochondrion
Interactions
In the nucleus, POLDIP2 has been shown to
interact
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with
PCNA,
while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid and the
AAA+ protease CLPXP
where it modulates both the specificity and stability of this proteolytic machine.
References
Further reading
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