Serine/threonine-protein kinase N1 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''PKN1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Interactions
Protein kinase N1 has been shown to
interact
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with:
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AKAP9
A-kinase anchor protein 9 is a protein that in humans is encoded by the ''AKAP9'' gene. AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450
Function
The A-kinase anchor pro ...
,
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Actinin, alpha 1
Alpha-actinin-1 is a protein that in humans is encoded by the ''ACTN1'' gene.
Function
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins a ...
,
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CCDC85B
Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the ''CCDC85B'' gene.
Function
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,
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NEFL
Neurofilament light polypeptide is a protein that in humans is encoded by the NEFL gene.
Structure
Neurofilament light polypeptide is a member of the intermediate filament protein family. This protein family consists of over 50 human proteins ...
,
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NEUROD2
Neurogenic differentiation factor 2 is a protein that in humans is encoded by the ''NEUROD2'' gene.
Function
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can ind ...
*
Phosphoinositide-dependent kinase-1
In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the ''PDPK1'' gene in humans. It is implicated in the development and progression of melanomas.
Function
P ...
,
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Phospholipase D1
Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the ''PLD1'' gene, though analogues are found in plants, fungi, prokaryotes, and even viruses.
History
The possibility of PLD1 was first mentioned in 1947 by authors Hanahan an ...
,
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RHOA
Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the ''RHOA'' gene. While the effects of RhoA activity are not all well known, it is ...
,
and
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Vimentin
Vimentin is a structural protein that in humans is encoded by the ''VIM'' gene. Its name comes from the Latin ''vimentum'' which refers to an array of flexible rods.
Vimentin is a Intermediate filament#Type III, type III intermediate filamen ...
.
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TRAF1
TNF receptor-associated factor 1 is a protein that in humans is encoded by the ''TRAF1'' gene.
Function
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate w ...
.
References
Further reading
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EC 2.7.11