PHTPP is a
synthetic,
nonsteroidal A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.
List of nonsteroidal steroid receptor mo ...
, and highly selective
antagonist of
ERβ
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ is encoded by ...
that is used in
scientific research
The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific ...
to study the function of this
receptor.
It possesses 36-fold selectivity for ERβ over
ERα
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein)
that is activated by the sex h ...
, and is a
silent antagonist of ERβ.
See also
*
Propylpyrazoletriol (PPT)
*
Methylpiperidinopyrazole (MPP)
*
(R,R)-Tetrahydrochrysene
(''R'',''R'')-Tetrahydrochrysene ((''R'',''R'')-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (''R'',''R'' ...
((R,R)-THC)
*
Diarylpropionitrile (DPN)
*
Prinaberel (ERB-041)
*
Liquiritigenin
*
Menerba
*
WAY-200070
References
Antiestrogens
Trifluoromethyl compounds
Phenols
Pyrazolopyrimidines
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