Prostaglandin E synthase (, or PGE synthase) is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

involved in

eicosanoid Eicosanoids are lipid signaling, signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length. Eicosa ...

and

glutathione Glutathione (GSH, ) is an organic compound with the chemical formula . It is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by sources ...

metabolism, a member of MAPEG family. It generates

prostaglandin E Prostaglandin E is a family of naturally occurring prostaglandins that are used as medications. Types include: * Prostaglandin E1 also known as alprostadil * Prostaglandin E2 also known as dinoprostone Both types are on the World Health Org ...

(PGE) from

prostaglandin H2 Prostaglandin H2 (PGH2), or prostaglandin H2 (PGH2), is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. The con ...

. The synthase generating PGE2 is a membrane-associated protein.

Isozymes

Humans express three prostaglandin-E synthase

isozyme In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. di ...

s, each encoded by a separate gene:

References

External links

* * EC 5.3.99 {{enzyme-stub