Paternally-expressed gene 3 protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''PEG3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
PEG3 is an
imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.
PEG3 is a transcription factor that binds to DNA
1-13via the
sequence motif
In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be related to biological function of the macromolecule. For example, an ''N''-glycosylation site motif can be defined as ''A ...
AGTnnCnnnTGGCT, which it binds to using multiple
Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.
Interactions
PEG3 has been shown to
interact with
SIAH2 and
SIAH1.
[
kjh-5oil2-*m
jhac-*n.,myr0.
]
References
Further reading
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