Programmed cell death protein 10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''PDCD10''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene.
Gene
Loss of function mutations in ''PDCD10'' result in the onset of Cerebral Cavernous Malformations (CCM) illness.
Therefore, this gene is also called ''CCM3''. Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and spinal cord made of dilated capillary vessels.
Interactions
CCM3 encodes a protein called Programmed Cell Death 10 (PDCD10). The function of this protein has only recently begun to be understood. PDCD10 has roles in vascular development and VEGF signaling1, apoptosis and functions as part of a larger signaling complex that includes germinal center kinase III.
Specifically, PDCD10 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
RP6-213H19.1
Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the ''MST4'' gene.
Function
The product of this gene is a member of the GCK group III family of kinas ...
,
STK25
Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the ''STK25'' gene.
Interactions
STK25 has been shown to interact with STRN, PDCD10 and MOBKL3
Mps one binder kinase activator-like 3 is an enzyme that in humans is ...
,
STRN
Striatin is a protein that in humans is encoded by the ''STRN'' gene.
Interactions
STRN has been shown to interact with:
* CTTNBP2NL,
* CTTNBP2,
* FAM40A,
* MOBKL3,
* PDCD10,
* PPP2CA,
* PPP2R1A,
* RP6-213H19.1,
* STK24,
* S ...
,[ ]STRN3
Striatin-3 is a protein that in humans is encoded by the ''STRN3'' gene.
Interactions
STRN3 has been shown to interact with:
* CTTNBP2NL,
* CTTNBP2,
* FAM40A,
* MOBKL3,
* PDCD10,
* PPP2CA,
* PPP2R1A,
* RP6-213H19.1,
* STK24, and
* ...
,[ ]MOBKL3
Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the ''MOBKL3'' gene.
Function
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expr ...
,[ ]CTTNBP2NL
CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the ''CTTNBP2NL'' gene. It is a substrate for phosphorylation.
Interactions
CTTNBP2NL has been shown to interact with:
* FAM40A, and
* MOBKL3,
* PDCD10,
* PPP2CA, ...
,[ ]STK24
Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the ''STK24'' gene located in the chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and i ...
FAM40A
Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the ''FAM40A'' gene.
Characteristics and secondary structure
FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 Dalton (unit), daltons. ...
.[
]
References
Further reading
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External links
www.angioma.org Angioma Alliancewww.ccm3.org CCM3 Action
{{Webarchive, url=https://web.archive.org/web/20211109113510/http://www.ccm3.org/ , date=2021-11-09
Genes mutated in mice