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The Platform Adaptive Trial of Novel Antivirals for Early Treatment of COVID-19 in the Community (PANORAMIC Trial) is a clinical trial in the United Kingdom to test the effectiveness of new
antiviral drug Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do n ...
s at the early stages of COVID-19 infections. The study aims to find out if antivirals can prevent the need for hospitalisation and help faster recovery for people aged over 50 and those at higher risk due to underlying health conditions. PANORAMIC is sponsored by the University of Oxford and funded by the National Institute for Health and Care Research (NIHR). The trial was launched in December 2021, and as of June 2022, over 25,000 people are enrolled as participants.


Overview

PANORAMIC is a
platform trial A platform trial is a type of prospective, disease-focused, Adaptive clinical trial, adaptive, Clinical trial, randomized clinical trial (RCT) that compares multiple, simultaneous and possibly differently-timed interventions against a single, consta ...
that will compare two groups who are having symptoms of COVID: one will receive standard NHS care and the other one will receive standard NHS care plus antiviral treatment. Participants can take part from home online or via phone and the antivirals are delivered to them.


Participants

People can enroll in the study if they had symptoms of COVID (confirmed by a test) less than 5 days prior to enrolling. They have to be either aged 50 or over, or have a preexisting health condition.


Treatments

The antivirals tested in the study will be molnupiravir and nirmatrelvir/ritonavir (Paxlovid).


Results


Molnupiravir

In December 2022, results from the trial showed that for higher risk, vaccinated adults molnupiravir does not reduce the chances of hospitalisation and death. However it leads to faster recovery and reduced viral load.


See also

*
COVID-19 drug development COVID-19 drug development is the research process to develop preventative therapeutic prescription drugs that would alleviate the severity of coronavirus disease 2019 (COVID-19). From early 2020 through 2021, several hundred drug companies, bi ...
* RECOVERY Trial *
Solidarity trial The Solidarity trial for treatments is a multinational Phase III-IV clinical trial organized by the World Health Organization (WHO) and partners to compare four untested treatments for hospitalized people with severe COVID-19 illness. The tria ...


References


External links

* {{Portal bar , Medicine , Viruses , COVID-19 Clinical trials COVID-19 pandemic in the United Kingdom Medical responses to the COVID-19 pandemic United Kingdom responses to the COVID-19 pandemic