PANC-1 is a human
pancreatic cancer
Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of ...
cell line
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells ...
isolated from a pancreatic carcinoma of
ductal cell origin.
PANC-1 was derived from the tissue of a 56-year-old male. The cells can
metastasize
Metastasis is a pathogenic agent's spreading from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, ...
but have poor differentiation abilities.
PANC-1 cells take 52 hours to double in population, have a modal chromosome number of 63, and show G6PD of the slow mobility type.
PANC-1 cells are known to have an epithelial morphology and are adherent in
cell culture
Cell culture or tissue culture is the process by which cell (biology), cells are grown under controlled conditions, generally outside of their natural environment. After cells of interest have been Cell isolation, isolated from living tissue, ...
flasks. The cells can be frozen and regrown in culture, provided that they are appropriately warmed. Additionally, PANC-1 cells have a tendency to clump, a feature which can be avoided with
trypsinization
Trypsinization is the process of cell dissociation using trypsin, a proteolytic enzyme which breaks down proteins, to dissociate adherent cells from the vessel in which they are being cultured. When added to cell culture, trypsin breaks down the ...
.
PANC-1 cells have been used to study the role of
keratin
Keratin () is one of a family of structural fibrous proteins also known as ''scleroproteins''. It is the key structural material making up Scale (anatomy), scales, hair, Nail (anatomy), nails, feathers, horn (anatomy), horns, claws, Hoof, hoove ...
reorganization during the migration of cancer cells, along with calcium-mediated actin reset in response to physiological changes.
See also
*
DU145
DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research.
The DU145 cell line was derived from a central nervous system metastasis, of p ...
*
BxPC-3 BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof.
BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, wi ...
*
MIA PaCa-2
References
{{Reflist
External links
Cellosaurus entry for PANC-1
Human cell lines