P2X purinoceptor 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''P2RX3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
Ligands
Antagonists
Not true antagonists, but negative allosteric modulators:
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Camlipixant
Camlipixant is an investigational new drug that is being evaluated for the treatment of chronic cough. It is a P2X3 receptor antagonist.
See also
* gefapixant
Gefapixant, sold under the brand name Lyfnua, is a medication used to treat c ...
(BLU-5937)
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Gefapixant
Gefapixant, sold under the brand name Lyfnua, is a medication used to treat chronic (long-term) cough. It acts as an antagonist of the P2RX3 receptor.
It was authorized for medical use in the European Union in September 2023.
Medical uses ...
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Opiranserin
Opiranserin (; developmental code name VVZ-149) is a selective and combined glycine GlyT2 transporter blocker ( = 0.86 μM), purine P2X3 receptor antagonist ( = 0.87 μM), and serotonin 5-HT2A receptor antagonist ( = 1.3 μM) ...
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Quercetin
Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor ...
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PSFL2915
The Professional Spring Football League (PSFL) was a proposed outdoor american football minor league slated to begin in 1992. The league was founded by Vincent Sette, a computer sales executive, while TV executive Rex Lardner served as commissioner ...
See also
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P2X purinoreceptor
The P2X receptors, also ATP-gated P2X receptor cation channel family, is a protein family that consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They bel ...
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Purinergic receptor
Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. Within the field of purinergic signalling, these receptors have been implicated in learning and memory, ...
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as sodium, Na+, potassium, K+, calcium, Ca2+, and/or chloride, Cl− to ...
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Nociceptor
A nociceptor (; ) is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, ...
References
Further reading
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External links
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Ion channels
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