With newer, non-invasive imaging techniques, the origin of other, so-called ''

adventitial The adventitia ( ) is the outer layer of fibrous connective tissue surrounding an organ. The outer layer of connective tissue that surrounds an artery, or vein – the tunica externa, is also called the ''tunica adventitia''. To some degree, it ...

sounds'' or heart clicks has been appreciated. These are short, high-pitched sounds. * The

mitral valve The mitral valve ( ), also known as the bicuspid valve or left atrioventricular valve, is one of the four heart valves. It has two Cusps of heart valves, cusps or flaps and lies between the atrium (heart), left atrium and the ventricle (heart), ...

in cases of

mitral stenosis Mitral stenosis is a valvular heart disease characterized by the Stenosis, narrowing of the opening of the mitral valve of the heart. It is almost always caused by Rheumatic Heart Disease, rheumatic valvular heart disease. Normally, the mitral va ...

may open with an ''opening snap'' on the beginning of

diastole Diastole ( ) is the relaxed phase of the cardiac cycle when the chambers of the heart are refilling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricul ...

. * Patients with

mitral valve prolapse Mitral valve prolapse (MVP) is a valvular heart disease characterized by the displacement of an abnormally thickened mitral valve leaflet into the atria of the heart, left atrium during Systole (medicine), systole. It is the primary form of myxom ...

may have a mid-systolic click along with a murmur, referred to as apical late systolic murmur. Early systolic clicks may also be present in some patients. *

Aortic The aorta ( ; : aortas or aortae) is the main and largest artery in the human body, originating from the left ventricle of the heart, branching upwards immediately after, and extending down to the abdomen, where it splits at the aortic bifurc ...

and

pulmonary stenosis Pulmonic stenosis, is a dynamic or fixed obstruction of flow from the right ventricle of the heart to the pulmonary artery. It is usually first diagnosed in childhood. Signs and symptoms Some individuals with mild PS may not experience any sympt ...

may cause an ejection click immediately after S₁.

References

{{Cardiovascular system symptoms and signs Symptoms and signs: Cardiac Audible medical signs