Omzotirome (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...

), formerly codenamed TRC-150094, is a

thyromimetic Thyromimetic drugs are synthetic agonists of the thyroid hormone receptor's isoforms TR α1, TRα2, TRβ1, or TRβ2, mimicking some or all of the effects of endogenously produced thyroid hormones that regulate metabolism. Some thyromimetic drugs ar ...

drug which acts as a metabolic modulator which restores

metabolic flexibility Metabolic flexibility is the capacity to alter metabolism in response to exercise or available fuel (especially fats and carbohydrates). Metabolic inflexibility was first described as the ability to generate energy through either aerobic or anaerobi ...

. It has been shown to improve

insulin resistance Insulin resistance (IR) is a pathological response in which cells in insulin-sensitive tissues in the body fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia. Insulin is a horm ...

and

hyperglycemia Hyperglycemia is a condition where unusually high amount of glucose is present in blood. It is defined as blood glucose level exceeding 6.9 mmol/L (125 mg/dL) after fasting for 8 hours or 10 mmol/L (180 mg/dL) 2 hours after eating. Blood gluc ...

, and is in Phase III human

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s for the treatment of Cardiometabolic-Based Chronic Disease (CMBCD) by improving

dysglycemia Dysglycemia is a general definition for any abnormalities in blood glucose levels. They include hyperglycemia, hypoglycemia, impaired glucose tolerance test, impaired fasting glucose, among others. __TOC__ Hyperglycemia If blood sugar levels rema ...

, dyslipidemia and hypertension.

References

{{pharm-stub Small-molecule drugs Thyroid Indenes Experimental diabetes drugs Pyrazoles Carboxylic acids