The emboliform nucleus (or anterior interposed nucleus) is a deep cerebellar nucleus that lies immediately to the

medial Medial may refer to: Mathematics * Medial magma, a mathematical identity in algebra Geometry * Medial axis, in geometry the set of all points having more than one closest point on an object's boundary * Medial graph, another graph that re ...

side of the

nucleus dentatus The dentate nucleus is a cluster of neurons, or nerve cells, in the central nervous system that has a dentate – tooth-like or serrated – edge. It is located within the deep white matter of each cerebellar hemisphere, and it is the largest sin ...

, and partly covering its hilum. It is one among the four pairs of deep cerebellar nuclei, which are from lateral to medial: the

dentate Dentate may refer to: * A species having dentition * An energy-dissipating baffle block in a spillway * An individual not being edentulous * Dentate gyrus of the hippocampus * Dentate nucleus of the cerebellum * Denticity in chemistry * Dentate l ...

, interposed (which consists of the emboliform and

globose A sphere () is a geometrical object that is a three-dimensional analogue to a two-dimensional circle. A sphere is the set of points that are all at the same distance from a given point in three-dimensional space.. That given point is the ...

), and fastigial nuclei. These nuclei can be seen using

Weigert's elastic stain Weigert's elastic stain is a combination of stains used in histology which is useful in identifying elastic fibers. Often orcein or a combination of resorcinol and fuchsine are used for staining. For counterstaining cell nuclei nuclear fast red o ...

. ''Emboliform'', from Ancient Greek, means "shaped like a plug or wedge".

Structure

The emboliform nucleus is a wedge-shaped structure of

gray matter Grey matter is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries. Grey matter is distingui ...

found at the medial side of the hilum of the

dentate nucleus The dentate nucleus is a cluster of neurons, or nerve cells, in the central nervous system that has a dentate – tooth-like or serrated – edge. It is located within the deep white matter of each cerebellar hemisphere, and it is the largest si ...

. Its

neuron A neuron, neurone, or nerve cell is an membrane potential#Cell excitability, electrically excitable cell (biology), cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous ...

s display a similar structure from those of the dentate nucleus. In some mammals the emboliform nucleus is continuous with the

globose nucleus The globose nucleus is one of the deep cerebellar nuclei. It is located medial to the emboliform nucleus and lateral to the fastigial nucleus. This nucleus contains primarily large and small multipolar neurons. The ''globose nucleus'' and embo ...

, forming together the

interposed nucleus The interposed nucleus is part of the deep cerebellar complex and is composed of the globose nucleus and the emboliform nucleus. It is located in the roof (dorsal aspect) of the fourth ventricle, lateral to the fastigial nucleus. It receives it ...

. When present, the interposed nucleus can be divided in an anterior and a posterior interposed nucleus, considered homologues of the emboliform and globose nuclei, respectively.

Function

As a part of the interposed nucleus, the emboliform participates in the

spinocerebellum The anatomy of the cerebellum can be viewed at three levels. At the level of gross anatomy, the cerebellum consists of a tightly folded and crumpled layer of cortex, with white matter underneath, several deep nuclei embedded in the white matter ...

, a system that regulates the precision of limb movements.

Axon An axon (from Greek ἄξων ''áxōn'', axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action ...

s leaving the emboliform exit through the

superior cerebellar peduncle In the human brain, the superior cerebellar peduncle (brachium conjunctivum) is a paired structure of white matter that connects the cerebellum to the midbrain. It consists mainly of efferent fibers, the cerebellothalamic tract that runs from a c ...

and reach the

red nucleus The red nucleus or nucleus ruber is a structure in the rostral midbrain involved in motor coordination. The red nucleus is pale pink, which is believed to be due to the presence of iron in at least two different forms: hemoglobin and ferritin. ...

in the

midbrain The midbrain or mesencephalon is the forward-most portion of the brainstem and is associated with vision, hearing, motor control, sleep and wakefulness, arousal ( alertness), and temperature regulation. The name comes from the Greek ''mesos'', " ...

and several

thalamic The thalamus (from Greek θάλαμος, "chamber") is a large mass of gray matter located in the dorsal part of the diencephalon (a division of the forebrain). Nerve fibers project out of the thalamus to the cerebral cortex in all directions, ...

nuclei which project into areas of the

cerebral cortex The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting o ...

that control limb movement.

References

External links

* https://web.archive.org/web/20150621011739/http://www.mona.uwi.edu/fpas/courses/physiology/neurophysiology/Cerebellum.htm * https://web.archive.org/web/20080405060224/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_30.htm
NIF Search - Emboliform Nucleus
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