Nuclear factor I (NF-I) is a family of closely related
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...
s. They constitutively bind as dimers to specific sequences of DNA with high affinity.
Family members contain an unusual
DNA binding domain that binds to the
recognition sequence
A recognition sequence is a DNA sequence to which a structural motif of a DNA-binding domain exhibits binding specificity. Recognition sequences are palindromes.
The transcription factor Sp1 for example, binds the sequences 5'-(G/T)GGGCGG(G/A)( ...
5'-TTGGCXXXXXGCCAA-
3'.
Subtypes include:
*
NFIA
*
NFIB
*
NFIC
*
NFIX
References
{{Transcription factors, g1
Transcription factors