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Northfield Laboratories Inc. (former NASDAQ: NFLD) was the maker of PolyHeme, a hemoglobin-based oxygen carrier (HBOC). The company was based in
Evanston, Illinois Evanston is a city in Cook County, Illinois, United States, situated on the North Shore (Chicago), North Shore along Lake Michigan. A suburb of Chicago, Evanston is north of Chicago Loop, downtown Chicago, bordered by Chicago to the south, Skok ...
, with Dr. Steven A. Gould as its
chief executive officer A chief executive officer (CEO), also known as a chief executive or managing director, is the top-ranking corporate officer charged with the management of an organization, usually a company or a nonprofit organization. CEOs find roles in variou ...
. As of May 31, 2005, the company had 68 employees. It was founded in 1985 and has since been a mainly
research and development Research and development (R&D or R+D), known in some countries as OKB, experiment and design, is the set of innovative activities undertaken by corporations or governments in developing new services or products. R&D constitutes the first stage ...
company. Northfield's only product was PolyHeme, an oxygen-carrying blood substitute, which failed to receive
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
(FDA) regulatory approval. On May 9, 2009, after being informed by the FDA the product's risks outweighed the benefits, the company shut down operations. During their operations, they incurred losses of about 220 million dollars. The corporation was also criticized for some design elements of its clinical trials related to the need to perform critical care and resuscitation while patients were in grave clinical conditions due to the mechanisms of injury incurred and the consequent inability of patients to provide informed consent for treatment.


See also

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Clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...
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Urgent care An urgent care center (UCC), also known as an urgent treatment centre (UTC) in the United Kingdom, is a type of walk-in clinic focused on the delivery of urgent ambulatory care in a dedicated medical facility outside of a traditional emergency depa ...
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Unethical Human Experimentation in the United States Numerous experiments which were performed on human test subjects in the United States in the past are now considered to have been unethical, because they were performed without the knowledge or informed consent of the test subjects. Such tests ...


References


External links


PolyHeme's patent.
Chemical companies of the United States Transfusion medicine Companies formerly listed on the Nasdaq Companies based in Evanston, Illinois {{US-company-stub