Nikolai Koltsov
   HOME

TheInfoList



OR:

Nikolai Konstantinovich Koltsov (; 14 July 1872 – 2 December 1940) was a Russian biologist and a pioneer of modern
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...
. Among his students were Nikolay Timofeeff-Ressovsky, Vladimir Pavlovich Efroimson, A.S. Serebrovsky, and Nikolay Dubinin. Along with his students, he demonstrated the fine structure of genes, and examined the structure of the cell and pioneered the idea of a
cytoskeleton The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. In eukaryotes, it extends from the cell nucleus to the cell membrane and is compos ...
. His career was cut short in Stalinist Russia after being falsely accused of supporting scientific racism. He died unexpectedly following government persecution and there are allegations that he was executed.


Biography

Koltsov was born in a well-to do family, his father was an accountant in a fur company, and graduated from
Moscow University Moscow State University (MSU), officially M. V. Lomonosov Moscow State University,. is a public research university in Moscow, Russia. The university includes 15 research institutes, 43 faculties, more than 300 departments, and six branches. Al ...
in 1894 and was a professor there (1895–1911). He established and directed the Institute of Experimental Biology in the middle of 1917, just before the
October Revolution The October Revolution, also known as the Great October Socialist Revolution (in Historiography in the Soviet Union, Soviet historiography), October coup, Bolshevik coup, or Bolshevik revolution, was the second of Russian Revolution, two r ...
. He was a member of the Agricultural Academy ( VASKhNIL). He was against the Tsarist regime but after the revolution, he opposed several policies of the new rule. In 1911 he left Moscow University and moved to the Shanyavsky Moscow City People's University. In 1920, Koltsov was arrested as a member of the non-existent "anti-Soviet Tactical Center" invented by the VCheKa. Prosecutor
Nikolai Krylenko Nikolai Vasilyevich Krylenko (, ; 2 May 1885 – 29 July 1938) was an Old Bolshevik and Soviet politician, military commander, and jurist. Krylenko served in a variety of posts in the Soviet law, Soviet legal system, rising to become Minis ...
demanded the death sentence for Koltsov (67 of around 1000 arrested people were executed).Vadim J. Birstein. ''The Perversion Of Knowledge: The True Story of Soviet Science.'' Westview Press (2004) However, after a personal appeal to
Vladimir Lenin Vladimir Ilyich Ulyanov ( 187021 January 1924), better known as Vladimir Lenin, was a Russian revolutionary, politician and political theorist. He was the first head of government of Soviet Russia from 1917 until Death and state funeral of ...
by
Maxim Gorky Alexei Maximovich Peshkov (;  – 18 June 1936), popularly known as Maxim Gorky (; ), was a Russian and Soviet writer and proponent of socialism. He was nominated five times for the Nobel Prize in Literature. Before his success as an aut ...
Koltsov was released and was restored to his position as the head of the Koltsov Institute of Experimental Biology.The politics of the Soviet Union made the idea of genes, particles that decided outcomes in life, as antithetical to the concept of individual freedom. Marxist ideologues also clubbed geneticists with eugenicists, racists, and fascists while also preferring ideas from
Lamarckism Lamarckism, also known as Lamarckian inheritance or neo-Lamarckism, is the notion that an organism can pass on to its offspring physical characteristics that the parent organism acquired through use or disuse during its lifetime. It is also calle ...
as promoted by
Trofim Lysenko Trofim Denisovich Lysenko (; , ; 20 November 1976) was a Soviet agronomist and scientist.''An ill-educated agronomist with huge ambitions, Lysenko failed to become a real scientist, but greatly succeeded in exposing of the “bourgeois enemies o ...
. In 1937 and 1939, the supporters of Lysenko published a series of propaganda articles against Nikolai Koltsov and
Nikolai Vavilov Nikolai Ivanovich Vavilov ( rus, Никола́й Ива́нович Вави́лов, p=nʲɪkɐˈlaj ɪˈvanəvʲɪtɕ vɐˈvʲiləf, a=Ru-Nikolay_Ivanovich_Vavilov.ogg; – 26 January 1943) was a Russian and Soviet Union, Soviet agronom ...
. They wrote: "The Institute of Genetics of the Academy of Sciences not only did not criticize Professor Koltsov's fascistic nonsense, but even did not dissociate itself from his "theories" which support the racial theories of fascists". His death in 1940 was claimed to have been due to a stroke. However, "the biochemist Ilya Zbarsky revealed that the unexpected death of Koltsov was a result of his poisoning by the
NKVD The People's Commissariat for Internal Affairs (, ), abbreviated as NKVD (; ), was the interior ministry and secret police of the Soviet Union from 1934 to 1946. The agency was formed to succeed the Joint State Political Directorate (OGPU) se ...
", the secret police of the Soviet Union. On the same day his wife, the scientist Maria Sadovnikova Koltsova, committed suicide.


Research

Nikolai Koltsov worked on
cytology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...
and
vertebrate Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebra ...
anatomy Anatomy () is the branch of morphology concerned with the study of the internal structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old scien ...
. In 1903 Koltsov proposed that the shape of cells was determined by a network of tubules forming a skeleton which was later termed as the
cytoskeleton The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. In eukaryotes, it extends from the cell nucleus to the cell membrane and is compos ...
. He saw the role of gel-sol transitions in the cytoplasm as key mechanisms for the cell structure. In 1927 Koltsov proposed that inherited traits would be inherited via a "giant hereditary molecule" which would be made up of "two mirror strands that would replicate in a semi-conservative fashion using each strand as a template". Koltsov used the expression ''omnis molecula ex molecula'' (every molecule comes from another molecule) based on Virchow's idea that all cells came from other cells. These ideas were confirmed to have been accurate in 1953 when
James D. Watson James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper in ''Nature'' proposing the double helix structure of the DNA molecule. Wats ...
and
Francis Crick Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the Nucleic acid doub ...
described the structure of
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
. Watson and Crick had apparently not heard of Koltsov. US geneticist Richard Goldschmidt wrote about him: "There was the brilliant Nikolai Koltsov, probably the best Russian zoologist of the last generation, an enviable, unbelievably cultured, clear-thinking scholar, admired by everybody who knew him". He also suggested that electrical forces were involved in intracellular movement. He termed it as cataphoresis.


Legacy

Koltsovo, a small municipality in
Novosibirsk Oblast Novosibirsk Oblast () is a federal subjects of Russia, federal subject of Russia (an oblast) located in southwestern Siberia. Its administrative center, administrative and economic center is the types of inhabited localities in Russia, city of N ...
, in 2003 obtained the status of the Science town of the Russian Federation and was named after Nikolai Koltsov. A new species of marine organisms ''Cadlina koltzovi'' was named after Nikolai Koltsov


References

{{DEFAULTSORT:Kolstov, Nikolai Konstantinovich 1872 births 1940 deaths Deaths by poisoning 19th-century biologists from the Russian Empire Geneticists from the Russian Empire Soviet biologists Soviet geneticists Corresponding members of the Saint Petersburg Academy of Sciences Corresponding Members of the Russian Academy of Sciences (1917–1925) Corresponding Members of the USSR Academy of Sciences Academicians of the VASKhNIL Fellows of the Royal Society of Edinburgh Burials at Vvedenskoye Cemetery Russian scientists