Neutrophil collagenase (, ''matrix metalloproteinase 8'', ''PMNL collagenase'', ''MMP-8'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: Cleavage of interstitial
collagen
Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a trip ...
s in the
triple helical domain. Unlike
EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I
This enzyme belongs to the peptidase family M10.
See also
*
Collagenase
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as ''Clostridium''. They are considered a virulence factor, facilitating the spread of ...
References
External links
*
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EC 3.4.24