Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4

EF hand The EF hand is a helix–loop–helix structural domain or ''motif'' found in a large family of calcium-binding proteins. The EF-hand motif contains a helix–loop–helix topology, much like the spread thumb and forefinger of the human hand, in ...

motifs (out of which only 2 or 3 bind calcium) and an N- myristoyl group.

Members of NCS family

* Highly evolutionarily conserved * NCS1 (Frequenin) *

VILIP-1 Visinin-like protein 1 is a protein that in humans is encoded by the ''VSNL1'' gene. This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of t ...

(Visinin-like-protein-1) *

HPCAL4 Hippocalcin like 4, also known as HPCAL4, is a human gene. Function The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-bindi ...

(Visinin-like-protein-2) * HPCAL1 (Visinin-like-protein-3) * hippocalcin *

neurocalcin Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains. It possesses a Ca2+/ myristoyl switch The subclass of neurocalcins are brain-specific prote ...

* recoverin * Guanylate cyclase activator proteins (GCAPs) * Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1 Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the ''KCNIP1'' gene. Function This gene encodes a member of the family of voltage-gated potassium ( Kv) channel-interacting proteins (KCNIPs, also ...

KCNIP2 Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the ''KCNIP2'' gene. Function This gene encodes a member of the family of voltage-gated potassium ( Kv) channel-interacting proteins (KCNIPs, also ...

Calsenilin Calsenilin is a protein that in humans is encoded by the ''KCNIP3'' gene. Function This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of pr ...

or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein),

KCNIP4 Kv channel-interacting protein 4 is a protein that in humans is encoded by the ''KCNIP4'' gene. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch o ...

References

External links

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NCS proteins
Protein families {{protein-stub