Neurohydrodynamics is a division of

neurophysics Neurophysics (or neurobiophysics) is the branch of biophysics dealing with the development and use of physical methods to gain information about the nervous system. Neurophysics is an interdisciplinary science using physics and combining it with oth ...

that focuses on the

hydrodynamics In physics and engineering, fluid dynamics is a subdiscipline of fluid mechanics that describes the flow of fluids—liquids and gases. It has several subdisciplines, including ''aerodynamics'' (the study of air and other gases in motion) and ...

of the neurological system. It applies physical principles and design concepts to neurophysics seeking to close the gap between

fluid mechanics Fluid mechanics is the branch of physics concerned with the mechanics of fluids ( liquids, gases, and plasmas) and the forces on them. It has applications in a wide range of disciplines, including mechanical, aerospace, civil, chemical and bio ...

and

neurosurgical Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peri ...

and

neurological Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal ...

medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

. It combines fluid mechanics principles with neuroscience to improve neurological disorder healthcare

diagnosis Diagnosis is the identification of the nature and cause of a certain phenomenon. Diagnosis is used in many different disciplines, with variations in the use of logic, analytics, and experience, to determine " cause and effect". In systems engin ...

monitoring Monitoring may refer to: Science and technology Biology and healthcare * Monitoring (medicine), the observation of a disease, condition or one or several medical parameters over time * Baby monitoring * Biomonitoring, of toxic chemical compounds, ...

and

therapy A therapy or medical treatment (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a medical diagnosis. As a rule, each therapy has indications and contraindications. There are many different ...

. Neurohydrodynamics investigates the role of intracranial fluid hydrodynamics (e.g.

cerebrospinal fluid Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the bra ...

cerebral blood flow Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. Arterie ...

, and interstitial fluid) in the

pathophysiology Pathophysiology ( physiopathology) – a convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury. Pathology is the ...

of neurological disorders such as

hydrocephalus Hydrocephalus is a condition in which an accumulation of cerebrospinal fluid (CSF) occurs within the brain. This typically causes increased intracranial pressure, pressure inside the skull. Older people may have headaches, double vision, poor ...

Chiari malformation Chiari malformation (CM) is a structural defect in the cerebellum, characterized by a downward displacement of one or both cerebellar tonsils through the foramen magnum (the opening at the base of the skull). CMs can cause headaches, difficu ...

, syringomyelia, pseudotumor cerebri, cerebral

vasospasm Vasospasm refers to a condition in which an arterial spasm leads to vasoconstriction. This can lead to tissue ischemia and tissue death (necrosis). Cerebral vasospasm may arise in the context of subarachnoid hemorrhage. Symptomatic vasospasm or de ...

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

multiple sclerosis Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This d ...

and cerebral

aneurysm An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus (s ...

. Neurohydrodynamics is an emerging discipline within

. Such an evolution is common as a new field transitions from being an

interdisciplinary Interdisciplinarity or interdisciplinary studies involves the combination of multiple academic disciplines into one activity (e.g., a research project). It draws knowledge from several other fields like sociology, anthropology, psychology, ec ...

specialization among already-established fields, to being considered a field in itself. Much of the work in neurohydrodynamics consists of

clinical research Clinical research is a branch of healthcare science that determines the safety and effectiveness ( efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatm ...

and

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...

computational modeling Computer simulation is the process of mathematical modelling, performed on a computer, which is designed to predict the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be dete ...

, spanning a broad array of subfields. Prominent neurohydrodynamic applications include the development of cerebral shunts, lumbar-peritoneal shunts, intrathecal pumps, neural drug delivery systems and various diagnostic and therapeutic

medical device A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assura ...

s ranging from clinical equipment to micro-implants. Neurohydrodynamics relies heavily on

neuroimaging Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Incre ...

modalities such as flow sensitized MRI.

Founding figures

* Anthony Marmarou (deceased) - Nemuth Distinguished Professor and Vice Chair of Research in the Department of Neurosurgery, Medical College of Virginia Hospitals of Virginia Commonwealth University. Well known for his commitment to research on Traumatic Brain Injury (TBI) and Normal Pressure Hydrocephalus (NPH), Dr. Marmarou was considered a world authority on fluid dynamics within the brain and spinal cord. Dr. Marmarou was the recipient of the prestigiou
Javits Neuroscience Investigator Award
from the

National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the U.S. National Institutes of Health (NIH). It conducts and funds research on brain and nervous system disorders and has a budget of just over US$2.03 billion. The ...

. *

Salomón Hakim Salomón Hakim Dow (4 June 1922 – 5 May 2011) was a Colombian neurosurgeon, researcher, and inventor. A descendant of Lebanese immigrants, he is known for his work on neurosurgery and for the precursor of the modern valve treatment for hydrocepha ...

(June 4, 1929 in

Barranquilla Barranquilla () is the capital district of Atlántico Department in Colombia. It is located near the Caribbean Sea and is the largest city and third port in the Caribbean Coast region; as of 2018 it had a population of 1,206,319, making it Col ...

Bogotá Bogotá (, also , , ), officially Bogotá, Distrito Capital, abbreviated Bogotá, D.C., and formerly known as Santa Fe de Bogotá (; ) during the Spanish period and between 1991 and 2000, is the capital city of Colombia, and one of the larges ...

- May 5, 2011) was a Colombian neurosurgeon, researcher, and inventor. A descendant of Lebanese immigrants, he is known for his work on

neurosurgery Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peri ...

and for the precursor of the modern valve treatment for

. * Hans Chiari (September 4, 1851 − 1916) was an Austrian pathologist who described in 1891 a brain malformation that is characterized by abnormalities in the region where the brain and spinal cord meet, and it causes part of the cerebellum to protrude through the foramen magnum (bottom of the skull) into the spinal canal. This was to be called the Arnold-Chiari malformation, named after Chiari and German pathologist, Julius Arnold (1835 − 1915). The malformation was given its name in 1907 by two of Dr. Arnold's students.

Founding figures

Notes

Further reading