Neuregulin 4 also known as NRG4 is a member of the

neuregulin Neuregulins are a family of four structurally related proteins that are part of the epidermal growth factor family, EGF family of proteins. These proteins have been shown to have diverse functions in the development of the nervous system and play ...

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

family which in humans is encoded by the ''NRG4''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 ( ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced

bladder cancer Bladder cancer is the abnormal growth of cells in the bladder. These cells can grow to form a tumor, which eventually spreads, damaging the bladder and other organs. Most people with bladder cancer are diagnosed after noticing blood in thei ...

while increased NRG4 expression correlates to better survival.

Function

Clinical significance

References

Further reading