Neoxaline is a bio-active ''

Aspergillus japonicus ''Aspergillus violaceofuscus'' is a species of fungus in the genus ''Aspergillus''. It belongs to the group of black Aspergilli which are important industrial workhorses. ''A. violaceofuscus'' belongs to the ''Nigri'' section. The species was fir ...

'' isolate. It is an

antimitotic A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout, and nail fungus. These drugs disrupt microtubules, which are structures that pull the ch ...

agent and shows weak inhibitory activity of

blood platelet Platelets or thrombocytes () are a part of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping to form a blood clot. Platelets have no cell nucleus; they are fragments of cytopla ...

aggregation. It stimulates the

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity o ...

. It has been synthesized through the "highly stereoselective introduction of a reverse prenyl group to create a quaternary carbon stereocenter using (−)-3a-hydroxyfuroindoline as a building block, construction of the indoline spiroaminal via cautious stepwise oxidations with cyclizations from the indoline, assembly of (Z)-dehydrohistidine, and photoisomerization of unnatural (Z)-neoxaline to the natural (E)-neoxaline."

References

Piperidine alkaloids Pyrrolidine alkaloids Mitotic inhibitors Imidazoles Heterocyclic compounds with 4 rings Methoxy compounds Cyclic ketones {{Alkaloid-stub

See also

References