Nariman Bomanshaw Mehta (April 20, 1920 – August 22, 2014) was an Indian-born American

organic chemist Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...

and

pharmacologist Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between ...

who designed, synthesized, and patented the organic compound

bupropion Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder, seasonal affective disorder, and to support smo ...

, marketed under the name

Wellbutrin Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder, seasonal affective disorder, and to support smoki ...

as an

antidepressant Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathi ...

and

smoking cessation Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking. Tobacco smoke contains nicotine, which is Addiction, addictive and can cause Substance dependence, dependence. As a resu ...

aid.

Early life and education

Mehta was born in

Bombay Mumbai ( ; ), also known as Bombay ( ; its official name until 1995), is the capital city of the Indian States and union territories of India, state of Maharashtra. Mumbai is the financial centre, financial capital and the list of cities i ...

, India into a

Parsi The Parsis or Parsees () are a Zoroastrian ethnic group in the Indian subcontinent. They are descended from Persian refugees who migrated to the Indian subcontinent during and after the Arab-Islamic conquest of Iran in the 7th century, w ...

Zoroastrian Zoroastrianism ( ), also called Mazdayasnā () or Beh-dīn (), is an Iranian religion centred on the Avesta and the teachings of Zarathushtra Spitama, who is more commonly referred to by the Greek translation, Zoroaster ( ). Among the wo ...

family. He attended

St. Xavier's College A multitude of schools and universities have been named after St. Francis Xavier, a Spanish Roman Catholic saint and co-founder of the Society of Jesus. This page lists notable educational institutions named after St. Xavier, arranged by country a ...

, from where he received

Bachelor of Science A Bachelor of Science (BS, BSc, B.S., B.Sc., SB, or ScB; from the Latin ') is a bachelor's degree that is awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Scienc ...

degrees in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

and

physics Physics is the scientific study of matter, its Elementary particle, fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge whi ...

and

Bachelor of Arts A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts deg ...

degrees in

English English usually refers to: * English language * English people English may also refer to: Culture, language and peoples * ''English'', an adjective for something of, from, or related to England * ''English'', an Amish ter ...

and

economics Economics () is a behavioral science that studies the Production (economics), production, distribution (economics), distribution, and Consumption (economics), consumption of goods and services. Economics focuses on the behaviour and interac ...

, and a

Master of Science A Master of Science (; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree. In contrast to the Master of Arts degree, the Master of Science degree is typically granted for studies in sciences, engineering and medici ...

degree. In 1939, he and fellow student Kaikhosrov D. Irani, later a noted academic in his own right, wrote and published a Textbook ''of Theoretical and Practical Physics''. Mehta won a Tata Scholarship and received a grant from

Wendell Willkie Wendell Lewis Willkie (born Lewis Wendell Willkie; February 18, 1892 – October 8, 1944) was an American lawyer, corporate executive and the 1940 History of the Republican Party (United States), Republican nominee for president. Willkie appeale ...

. In 1947 Mehta went to the United States, where he earned a PhD in chemistry from

The University of Kansas The University of Kansas (KU) is a public research university with its main campus in Lawrence, Kansas, United States. Two branch campuses are in the Kansas City metropolitan area on the Kansas side: the university's medical school and hospital ...

. Mehta's 1952 dissertation was titled ''I. Use of the Hammett equation in the prediction of product ratios in the Schmidt reaction of unsymmetrical diarylethylenes: II. The synthesis of possible emetine intermediates''. He had two daughters and a son.

Career

Seagram The Seagram Company Ltd. (which trade name, traded as Seagram's) was a Canadian multinational beverage and during the last few years of its existence, entertainment Conglomerate (company), conglomerate formerly headquartered in Montreal, Quebec. ...

invited Mehta to the United States as a trainee in their research lab, where he learned about

fermentation Fermentation is a type of anaerobic metabolism which harnesses the redox potential of the reactants to make adenosine triphosphate (ATP) and organic end products. Organic molecules, such as glucose or other sugars, are catabolized and reduce ...

and

distillation Distillation, also classical distillation, is the process of separating the component substances of a liquid mixture of two or more chemically discrete substances; the separation process is realized by way of the selective boiling of the mixt ...

. During his time at Seagram, Mehta studied the antibiotic

Penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...

. While teaching chemistry at

Central State University Central State University (CSU) is a public, historically black land-grant university in Wilberforce, Ohio, United States. It is a member-school of the Thurgood Marshall College Fund. Established by the state legislature in 1887 as a two-y ...

Wilberforce, Ohio Wilberforce is a census-designated place (CDP) in Greene County, Ohio, United States. The population was 2,410 at the 2020 census. History After Wilberforce University was established in 1856, the community was also named for the English stat ...

, Mehta joined the pharmaceutical company Burroughs Wellcome, Inc., now

GlaxoSmithKline GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers an ...

, where he worked on potential neuropsychopharmacological drugs and designed, synthesized, and patented (in 1969) the compound

Bupropion Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder, seasonal affective disorder, and to support smo ...

(BW 323U66) that was approved for use as an

in 1985 and sold under the trade name Wellbutrin. Another application of the drug was as a

aid.

Selected publications

* * *

Notes

References

* * * {{DEFAULTSORT:Mehta, Nariman 1920 births 2014 deaths 20th-century Indian inventors Indian pharmacologists Indian emigrants to the United States Indian biochemists GSK plc St. Xavier's College, Mumbai alumni University of Kansas alumni 20th-century Indian chemists Scientists from Mumbai American people of Parsi descent Parsi people from Mumbai Parsi people