Nafadotride is a
dopamine antagonist
A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and have been used in t ...
with some
selectivity
Selectivity may refer to:
Psychology and behaviour
* Choice, making a selection among options
* Discrimination, the ability to recognize differences
* Socioemotional selectivity theory, in social psychology
Engineering
* Selectivity (radio), a ...
for the
D3 subtype (9.6-fold preference for D
3 over D
2).
[Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. ''Nature''. 1999;400:371–375.]
See also
*
GSK-598809
GSK-598809 is a binding selectivity, selective dopamine D3 receptor, D3 receptor receptor antagonist, antagonist that is or was under development for the treatment of substance use disorder, substance-related disorders, smoking withdrawal, and ea ...
*
PNU-99,194
PNU-99,194(A) (or U-99,194(A)) is a drug which acts as a moderately selective D3 receptor antagonist with ~15-30-fold preference for D3 over the D2 subtype. Though it has substantially greater preference for D3 over D2, the latter receptor doe ...
*
SB-277,011-A
SB-277,011A is a drug which acts as a potent and selective dopamine D3 receptor antagonist, which is around 80–100times selective for D3 over D2, and lacks any partial agonist activity.
SB-277,011A is used in the study of addiction to stimul ...
References
Carboxamides
Dopamine antagonists
Naphthol ethers
Nitriles
Pyrrolidines
Methoxy compounds
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