Linopristin/flopristin (development codes NXL103 and XRP 2868) is an experimental drug candidate under

development Development or developing may refer to: Arts *Development (music), the process by which thematic material is reshaped * Photographic development *Filmmaking, development phase, including finance and budgeting * Development hell, when a proje ...

by Novexel. It is an oral

streptogramin Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors. Streptogramin A, Streptogramins are effective in the treatment of Vancomycin-resistant Staphylococcus aureus, vancomycin-resistant ''Staphylococcus aureus'' (V ...

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

that has potent ''

in vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...

'' activity against certain

Gram-positive bacteria In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. The Gram stain ...

including methicillin resistant ''Staphylococcus aureus'' (MRSA), as well as the important respiratory pathogens including

penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...

macrolide Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides belong to the polyketide class of natural products. ...

- and

quinolone Quinolone may refer to: * 2-Quinolone * 4-Quinolone * Quinolone antibiotic Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They ar ...

-resistant strains.Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia
, drugs.com It is a combination of linopristin and

flopristin Flopristin is a semi-synthetic antibiotic of the streptogramin A class. It is a fluorinated derivative In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect t ...

Clinical trials

Positive results have been reported from a

phase II trial The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...

comparing it with

amoxicillin Amoxicillin is an antibiotic medication belonging to the aminopenicillin class of the penicillin family. The drug is used to treat bacterial infections such as middle ear infection, strep throat, pneumonia, skin infections, odontogenic inf ...

. Another phase II trial began in 2010 comparing it with

linezolid Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, va ...

for treatment of acute bacterial skin and skin structure infections (ABSSSI). No development activity has been reported since 2015.

References

Antibiotics Abandoned drugs {{antibiotic-stub