NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
which in humans is encoded by the ''NOX5''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
NOX5 is a novel
NADPH oxidase that generates
superoxide.
Nox5 interacts with
c-abl, superoxide production leads to
phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.
References
Further reading
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EF-hand-containing proteins
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