H/ACA ribonucleoprotein complex subunit 2 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''NHP2''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Identifiers

This gene is a member of the H/ACA snoRNPs (small nucleolar

ribonucleoproteins Nucleoproteins are proteins conjugated with nucleic acids (either DNA or RNA). Typical nucleoproteins include ribosomes, nucleosomes and viral nucleocapsid proteins. Structures Nucleoproteins tend to be positively charged, facilitating inter ...

) gene family. snoRNPs are involved in various aspects of

rRNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal ...

processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the

DKC1 H/ACA ribonucleoprotein complex subunit 4 is a protein that in humans is encoded by the gene ''DKC1''. Dyskerin is a pseudouridine synthase enzyme which is part of the TruB family of enzymes. Dyskerin is an L-shaped protein of 514 residues ...

NOLA1 H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the ''GAR1'' gene. Function This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspec ...

and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of

nucleoli The nucleolus (; : nucleoli ) is the largest structure in the nucleus of eukaryotic cells. It is best known as the site of ribosome biogenesis. The nucleolus also participates in the formation of signal recognition particles and plays a ro ...

and coiled (

Cajal Cajal: * Santiago Ramón y Cajal, Spanish histologist, physician, pathologist * Fortún Garcés Cajal, medieval Spanish nobleman * Nicolae Cajal (1919–2004), Romanian Jewish physician, academic, politician, philanthropist * Cajal Institute, a neu ...

) bodies in the nucleus. Both 18S rRNA production and rRNA

pseudouridylation Pseudouridine (5-ribosyluracil, abbreviated by the Greek letter psi- Ψ) is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. Pseudouridine is the most abundant ...

are impaired if any of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different

isoforms A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. While many perform the same or similar biological roles, some isoforms have uniqu ...

have been found for this gene.

Identifiers

References

Further reading