enzymology An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

, a NADPH dehydrogenase () is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

that

catalyzes Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...

the

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

:NADPH + H⁺ + acceptor

\rightleftharpoons

NADP⁺ + reduced acceptor The 3 substrates of this enzyme are

NADPH Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require N ...

, H⁺, and

acceptor Acceptor may refer to: * Acceptor (accounting), the addressee of a bill of exchange * In the Indian Contract Act of 1872, the acceptor is the person to whom a proposal is made, and who has communicated his or her acceptance of the said proposal * ...

, whereas its two

products Product may refer to: Business * Product (business), an item that can be offered to a market to satisfy the desire or need of a customer. * Product (project management), a deliverable or set of deliverables that contribute to a business solution ...

are NADP⁺ and

reduced acceptor An electron acceptor is a chemical entity that accepts electrons transferred to it from another compound. Electron acceptors are oxidizing agents. The electron accepting power of an electron acceptor is measured by its redox potential. In the si ...

. This enzyme belongs to the family of

oxidoreductase In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ut ...

s, specifically those acting on NADH or NADPH with other acceptors. It has 2

cofactors Cofactor may also refer to: * Cofactor (biochemistry), a substance that needs to be present in addition to an enzyme for a certain reaction to be catalysed * A domain parameter in elliptic curve cryptography, defined as the ratio between the order ...

FAD A fad, trend, or craze is any form of collective behavior that develops within a culture, a generation, or social group in which a group of people enthusiastically follow an impulse for a short time period. Fads are objects or behaviors tha ...

, and FMN.

Nomenclature

The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...

of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include * NADPH2 diaphorase * NADPH diaphorase * old yellow enzyme * diaphorase * dihydronicotinamide adenine dinucleotide phosphate dehydrogenase * NADPH-dehydrogenase * NADPH-diaphorase * NADPH2-dehydrogenase * reduced nicotinamide adenine dinucleotide phosphate dehydrogenase * TPNH dehydrogenase * TPNH-diaphorase * triphosphopyridine diaphorase * triphosphopyridine nucleotide diaphorase * NADPH2 dehydrogenase * NADPH:(acceptor) oxidoreductase.

References

* * * * * *

Nomenclature

References

Further reading