Myosmine is an
alkaloid
Alkaloids are a class of basic
BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Th ...
found in
tobacco
Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ch ...
and other plants.
Chemically, it is closely related to
nicotine. It inhibits
aromatase
Aromatase (), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze ma ...
seven fold more potently than nicotine.
It also releases
dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. Dopamine constitutes about 8 ...
in adult but not adolescent rats.
See also
*
Catharanthine
Catharanthine is a terpene indole alkaloid produced by the medicinal plant '' Catharanthus roseus'' and ''Tabernaemontana divaricata''. Catharanthine is derived from strictosidine, but the exact mechanism by which this happens is currently unkno ...
*
Nicotelline
*
Pozanicline
*
PHA-543,613
PHA-543,613 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treat ...
References
Nicotinic agonists
Pyridine alkaloids
Pyrrolidines
Alkaloids found in Nicotiana
3-Pyridyl compounds
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