Mykhaylenko or Mykhailenko () is a Ukrainian last name derived from the Ukrainian first name Mykhailo or Mykhaylo. Russian spelling: Mikhailenko or Mikhaylenko. It may refer to: * Dmitry Mikhaylenko (footballer, born 1995), Russian football player * Dmitry Mikhaylenko (footballer, born 2000), Russian football player * Dmytro Mykhaylenko (born 1973), Soviet and Ukrainian football player and coach * Volodymyr Mykhailenko (born 1973), retired male decathlete from Ukraine

See also