Mucrolysin (, ''Trimeresurus metalloendopeptidase A'', ''mucrotoxin A'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...
: Cleavage of Ser
9-His, His
10-Leu, Ala
14-Leu, Leu
15-Tyr and Tyr
16-Leu bonds in
insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabol ...
B chain
This
endopeptidase
Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from end-pieces of terminal amino acids. For this ...
from the venom of Taiwan
habu snake
is a Ryukyuan and Japanese name referring to certain venomous snakes:
* The following species are found in the Ryukyu Islands of Japan:
** ''Protobothrops elegans'', a.k.a. the Sakishima habu, found in the southern Ryukyu Islands
** ''Protobothr ...
(''
Protobothrops mucrosquamatus
''Protobothrops mucrosquamatus'' is a venomous pit viper species endemic to Asia. Common names include: brown-spotted pit viper,Gumprecht A, Tillack F, Orlov NL, Captain A, Ryabov S. 2004. ''Asian Pitvipers''. Geitje Books. Berlin. 1st Edition. ...
'').
References
External links
*
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EC 3.4.24