Mucrolysin (, ''Trimeresurus metalloendopeptidase A'', ''mucrotoxin A'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: Cleavage of Ser
9-His, His
10-Leu, Ala
14-Leu, Leu
15-Tyr and Tyr
16-Leu bonds in
insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (''INS)'' gene. It is the main Anabolism, anabolic hormone of the body. It regulates the metabol ...
B chain
This
endopeptidase
Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from end-pieces of terminal amino acids. For this r ...
from the venom of Taiwan
habu snake (''
Protobothrops mucrosquamatus
''Protobothrops mucrosquamatus'' is a pit viper species endemic to Asia. Common names include: brown-spotted pit viper,Gumprecht A, Tillack F, Orlov NL, Captain A, Ryabov S. 2004. ''Asian Pitvipers''. Geitje Books. Berlin. 1st Edition. 368 pp. . ...
'').
References
External links
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EC 3.4.24