Mothers against decapentaplegic is a protein from the SMAD family that was discovered in ''

Drosophila ''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or p ...

''. During ''Drosophila'' research, it was found that a mutation in the gene in the mother repressed the gene

decapentaplegic ''Decapentaplegic'' (''Dpp'') is a key morphogen involved in the development of the fruit fly ''Drosophila melanogaster'' and is the first validated secreted morphogen. It is known to be necessary for the correct patterning and development of the ...

in the embryo. The phrase "Mothers against" was added as a humorous take-off on organizations opposing various issues e.g.

Mothers Against Drunk Driving Mothers Against Drunk Driving (MADD) is a non-profit organization in the United States, Canada ( MADD Canada) and Brazil that seeks to stop driving with any amount of alcohol in the bloodstream, support those affected by drunk driving, prevent un ...

(MADD); and based on a tradition of such unusual naming within the gene research community. Several human homologues are known: * Mothers against decapentaplegic homolog 1 *

Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the ''SMAD2'' gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the ''Dr ...

Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by ...

* Mothers against decapentaplegic homolog 4 * Mothers against decapentaplegic homolog 5 * Mothers against decapentaplegic homolog 6 * Mothers against decapentaplegic homolog 7 * Mothers against decapentaplegic homolog 9

References

{{reflist Proteins SMAD (protein)