Moperone (Luvatren, since discontinued) is a

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics m ...

of the

butyrophenone Butyrophenone is an organic compound with the formula C6H5C(O)C3H7. It is a colorless liquid. The butyrophenone structure—a ketone flanked by a phenyl ring and a butyl chain—forms the basis for many other chemicals containing various subst ...

class which is marketed in Japan for the treatment of

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wi ...

. It is an antagonist for the D₂ (''K_i'' 0.7–1.9 nM), D₃ (''K_i'' 0.1–1 nM), and 5-HT_2A (''K_i'' 52 nM) receptors. It also has a high binding affinity for the sigma receptors.

References

Abandoned drugs Tertiary alcohols Butyrophenone antipsychotics Fluoroarenes 4-Phenylpiperidines Typical antipsychotics 4-Tolyl compounds {{nervous-system-drug-stub