Monongahela virus (MGLV) is a

single-stranded When referring to DNA transcription, the coding strand (or informational strand) is the DNA strand whose base sequence is identical to the base sequence of the RNA transcript produced (although with thymine replaced by uracil). It is this stra ...

negative-sense In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, ...

Orthohantavirus ''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses. Orthohantav ...

'' virus of

zoonotic A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. ...

origin that causes

hantavirus pulmonary syndrome Hantavirus pulmonary syndrome (HPS) is one of two potentially fatal syndromes of zoonotic origin caused by species of hantavirus. These include Black Creek Canal virus (BCCV), New York orthohantavirus (NYV), Monongahela virus (MGLV), '' Sin N ...

Discovery of virus

Monongahela virus was first detected in ''

Peromyscus maniculatus nubiterrae ''Peromyscus maniculatus'' is a rodent native to eastern North America. It is most commonly called the eastern deer mouse; when formerly grouped with the western deer mouse (''P. sonoriensis''), it was referred to as the North American deermo ...

'' (

Cloudland deer mice ''Peromyscus maniculatus'' is a rodent native to eastern North America. It is most commonly called the eastern deer mouse; when formerly grouped with the western deer mouse (''P. sonoriensis''), it was referred to as the North American deermo ...

) captured in the

Monongahela National Forest The Monongahela National Forest is a national forest located in the Allegheny Mountains of eastern West Virginia, USA. It protects over of federally managed land within a proclamation boundary that includes much of the Potomac Highlands Regio ...

West Virginia West Virginia is a state in the Appalachian, Mid-Atlantic and Southeastern regions of the United States.The Census Bureau and the Association of American Geographers classify West Virginia as part of the Southern United States while the ...

in 1985.

Transmission

This member virus of ''

Sin Nombre orthohantavirus ''Sin Nombre orthohantavirus'' (SNV) (from Spanish, meaning "without a name") is the prototypical etiologic agent of hantavirus cardiopulmonary syndrome (HCPS). Discovered in 1993 near the Cañon de la Muerte on the Navajo Reservation, it was ...

'' has not been shown to transfer from person to person. Transmission by aerosolized rodent excreta still remains the only known way the virus is transmitted to humans. In general, droplet and/or

fomite A fomite () or fomes () is any inanimate object that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host. Transfer of pathogens by fomites A fomite is any ...

transfer has not been shown in the hantaviruses in either the hemorrhagic or pulmonary forms. In two cases in

Pennsylvania Pennsylvania (; (Pennsylvania Dutch: )), officially the Commonwealth of Pennsylvania, is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States. It borders Delaware to its southeast, Ma ...

, the patients were living in rural areas and had recent exposure to rodent excreta prior to the onset of symptoms. Both patients developed rapid onset of respiratory distress and

pulmonary edema Pulmonary edema, also known as pulmonary congestion, is excessive liquid accumulation in the tissue and air spaces (usually alveoli) of the lungs. It leads to impaired gas exchange and may cause hypoxemia and respiratory failure. It is du ...

, believed to be the result of

cytokine storm A cytokine storm, also called hypercytokinemia, is a physiological reaction in humans and other animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. Norm ...

, and both expired within 5 days of onset of symptoms.

References

External links

Sloan Science and Film / Short Films / Muerto Canyon
by Jen Peel 29 minutes

by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico

Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae

{{Taxonbar, from=Q16985924 Viral diseases Hantaviridae Rodent-carried diseases Biological weapons Infraspecific virus taxa

Discovery of virus

Transmission

See also

References

External links