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Mohan Mishra (19 May 1937 - 6 May 2021) was an Indian physician, known for his studies on
Visceral leishmaniasis Visceral leishmaniasis (VL), also known as kala-azar (Hindi: kālā āzār, "black sickness") or "black fever", is the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality. Leishmaniasis ...
, (''Kala Azar'') and its treatment using
Amphotericin B Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. Fo ...
, regarded by many as a pioneering attempt. The
Government of India The Government of India ( ISO: ; often abbreviated as GoI), known as the Union Government or Central Government but often simply as the Centre, is the national government of the Republic of India, a federal democracy located in South Asia, ...
honoured him, in 2014, with the award of
Padma Shri Padma Shri (IAST: ''padma śrī''), also spelled Padma Shree, is the fourth-highest civilian award of the Republic of India, after the Bharat Ratna, the Padma Vibhushan and the Padma Bhushan. Instituted on 2 January 1954, the award is confe ...
, the fourth highest civilian award, for his contributions to the fields of medicine.


Biography

Mohan Mishra was born in Koilakh, in the
Madhubani district Madhubani district is one of the thirty-eight List of districts of Bihar, districts of Bihar, India, and is a part of Darbhanga division. Its administrative headquarters are located in Madhubani, India, Madhubani. The district has an area of ...
of the Indian state of
Bihar Bihar (; ) is a state in eastern India. It is the 2nd largest state by population in 2019, 12th largest by area of , and 14th largest by GDP in 2021. Bihar borders Uttar Pradesh to its west, Nepal to the north, the northern part of West ...
on 19 May 1937. After securing his medical credentials, Dr. Mishra started his career as a resident medical officer at
Darbhanga Medical College and Hospital Darbhanga Medical College and Hospital is a government medical college having hospital facilities at Darbhanga, Bihar. It was established in the year 1946. College is currently affiliated with Aryabhatta Knowledge University. History The m ...
(DMCH) in 1962 where he continued till 1995. During his stint at the DMCH, he took a sabbatical in 1970 to secure MRCP from the UK. In 1979, Mishra became the Professor of the General Medicine department. Another higher degree of FRCP was obtained in 1984 from Edinburgh and two years later, in 1986, he became the Head of the Department of General Medicine at the DMCH. He also secured an FRCP from London in 1988. Dr. Mishra retired in 1995, voluntarily ending his career at the DMCH.


Legacy

Mishra's studies on
Visceral leishmaniasis Visceral leishmaniasis (VL), also known as kala-azar (Hindi: kālā āzār, "black sickness") or "black fever", is the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality. Leishmaniasis ...
are considered by many as his most notable contribution.
Leishmaniasis Leishmaniasis is a wide array of clinical manifestations caused by parasites of the trypanosome genus '' Leishmania''. It is generally spread through the bite of phlebotomine sandflies, '' Phlebotomus'' and ''Lutzomyia'', and occurs most f ...
, the second largest parasitic killer after
Malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or deat ...
and known locally as ''Kala Azar'', was a common disease in the area and, after extensive research funded by the
World Health Organization The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level o ...
, Dr. Mishra proposed the use of
Amphotericin B Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. Fo ...
(Fungizone) to combat the disease through an article he published in Lancet in 1991. The proposal is regarded as a pioneering one and the drug is the one most commonly used the world over to treat Kala Azar. Mishra is also credited with research on arsenic in drinking water. His studies on the subject, assisted by his son, Narottam Mishra who is an information scientist at the
Kameshwar Singh Darbhanga Sanskrit University Kameshwar Singh Darbhanga Sanskrit University (KSDSU) is a state university located at Darbhanga, Bihar, India, dedicated to the teaching and promotion of Sanskrit. History KSDSU was established in 1961, with the scholar Umesh Mishra as its ...
, have been successful in finding a cost-effective way to eliminate arsenic from drinking water by using food-grade
alum An alum () is a type of chemical compound, usually a hydrated double sulfate salt of aluminium with the general formula , where is a monovalent cation such as potassium or ammonium. By itself, "alum" often refers to potassium alum, with t ...
. He has shown that Brahmi (
Bacopa monnieri ''Bacopa monnieri'' is a perennial, creeping herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America. It is known by the common names water hyssop, waterhyssop, brahmi, thyme-leafed ...
), a herb traditionally used in
India India, officially the Republic of India ( Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the ...
, can be effective in the treatment of
Dementias Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affec ...
. This study is registered in a
WHO Who or WHO may refer to: * Who (pronoun), an interrogative or relative pronoun * Who?, one of the Five Ws in journalism * World Health Organization Arts and entertainment Fictional characters * Who, a creature in the Dr. Seuss book ''Horton Hear ...
Primary Registry (ISRCTN18407424). His study was presented as an eposter at the Innovation in Medicine 2018 RCP annual conference, London 25–26 June 2018 (RCP18-EP-196: BRAHMI (Bacopa monnieri Linn) in the Treatment of Dementias- A Pilot Study) and it has been published in Future Healthcare Journal. Dr. Mishra is the author of ''A Textbook of Clinical Medicine'', published by the Oxford University Press and ''Clinical Methods in Medicine'' a guide on clinical examination of patients. * He has also written several non fiction books such as: * ''Unfinished Story: A History of the Indian Freedom Movement 1857-1947'' * ''Building an Empire - Chanakya Revisited'' * ''Mangal Pandey to Lakshmibai: A Story of the Indian Mutiny 1857'' * ''India Through Alien Eyes'' Mishra has also written many articles in international scientific journals such as Lancet and
British Medical Journal ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origin ...
. Mohan Mishra lived in Bengali Tola in
Laheriasarai Laheriasarai is a city in North Bihar and considered as ''twin-city'' of Darbhanga. It has had a long cultural history. It has long been an integral part of Mithila and has a religious significance for many Hindus. Hindi, Maithili, and Urdu a ...
, the twin city of
Darbhanga Darbhanga is the fifth-largest city and municipal corporation in the Indian state of Bihar situated centrally in Mithila region. Darbhanga is the headquarters of the Darbhanga district and the Darbhanga division. It was the seat of the erst ...
, in North Bihar engaging himself with social activities such as free medical camps in remote villages in the
Darbhanga Darbhanga is the fifth-largest city and municipal corporation in the Indian state of Bihar situated centrally in Mithila region. Darbhanga is the headquarters of the Darbhanga district and the Darbhanga division. It was the seat of the erst ...
,
Jhanjharpur Jhanjharpur is a town and a sub-division in the Madhubani district of the state of Bihar, IndiaJhanjharpur is well connected to the other cities of India with railways Jhanjharpur town is connected with, Kamla Balan bridge, a century-old 220& ...
and Madhubani districts.


Positions

Mohan Mishra has served on two expert committees on Kala Azar set up by the
Government of Bihar The Government of Bihar, known locally as the State Government, is the supreme governing authority of the Indian state of Bihar and its 9 divisions which consist of 38 districts . It consists of an executive, led by the Governor of Bihar, a ju ...
and the
Government of India The Government of India ( ISO: ; often abbreviated as GoI), known as the Union Government or Central Government but often simply as the Centre, is the national government of the Republic of India, a federal democracy located in South Asia, ...
and has been an expert member of the
Union Public Service Commission The Union Public Service Commission ( ISO: ), commonly abbreviated as UPSC, is India's premier central recruitment agency for recruitment of all the Group 'A' officers under Government of India. It is responsible for appointments to and exam ...
(UPSC). He has also served as the Inspector of the
Medical Council of India The Medical Council of India (MCI) was a statutory body for establishing uniform and high standards of medical education in India until its dissolution on 25 September 2020 when it was replaced by National Medical Commission. The Council gran ...
for the master's degree examinations of
Assam University Assam University is a collegiate central public university located at Silchar, Assam, India. It was founded in the year 1994 by the provisions of an act enacted by the Parliament of India. The Governor of Assam is the Chief Rector and the ...
,
Silchar Silchar is a city and the headquarters of the Cachar district of the state of Assam, India. It is located south east of Guwahati. It was founded by Captain Thomas Fisher in 1832 when he shifted the headquarters of Cachar to Janiganj in Silchar. ...
and
Tamil University The Tamil University is a Public university, public State university (India), state university located in Thanjavur, Tamil Nadu, India. It was established to provide higher research in the Tamil language. Location The university is s ...
,
Tanjavur Thanjavur (), also Tanjore, Pletcher 2010, p. 195 is a city in the Indian state of Tamil Nadu. Thanjavur is the 11th biggest city in Tamil Nadu. Thanjavur is an important center of South Indian religion, art, and architecture. Most of the Gr ...
. His research paper presentations at various national and international scientific conferences included the annual conferences of the Association of Physicians of India and the
World Congress of Cardiology The World Heart Federation (WHF) is a non-governmental organization based in Geneva, Switzerland, formed in 1972. The current President for World Heart Federation is Fausto Pinto. In 1978 the International Society of Cardiology merged with the Int ...
, held in 1986 at Washington DC.


Awards and recognition

Mohan Mishra is a recipient of the Dr Rajendra Prasad Oration award which the Rajendra Prasad Memorial Research Institute, Patna conferred on him for his studies on Kala Azar. He has been honoured by the Delhi Administration for his literary work on the
Indian freedom movement The Indian independence movement was a series of historic events with the ultimate aim of ending British Raj, British rule in India. It lasted from 1857 to 1947. The first nationalistic revolutionary movement for Indian independence emerged ...
. His book, ''India Through Alien Eyes'', won the ''Wishing Shelf Award'' in 2012. The Government of India awarded him the
Padma Shri Padma Shri (IAST: ''padma śrī''), also spelled Padma Shree, is the fourth-highest civilian award of the Republic of India, after the Bharat Ratna, the Padma Vibhushan and the Padma Bhushan. Instituted on 2 January 1954, the award is confe ...
, in 2014, by including him in the
Republic day Republic Day is the name of a holiday in several countries to commemorate the day when they became republics. List January 1 January in Slovak Republic The day of creation of Slovak republic. A national holiday since 1993. Officially ca ...
honours.


Publications

* * * * * *


See also

*
Leishmaniasis Leishmaniasis is a wide array of clinical manifestations caused by parasites of the trypanosome genus '' Leishmania''. It is generally spread through the bite of phlebotomine sandflies, '' Phlebotomus'' and ''Lutzomyia'', and occurs most f ...
*
Amphotericin B Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. Fo ...


References

{{DEFAULTSORT:Mishra, Mohan 1937 births 2021 deaths Recipients of the Padma Shri in medicine 20th-century Indian medical doctors Writers from Bihar Indian medical writers Indian medical researchers Scientists from Bihar Indian male writers People from Madhubani district