Moesin is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''MSN''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Moesin (for membrane-organizing extension spike protein) is a member of the
ERM protein family which includes
ezrin
Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the ''EZR'' gene.
Structure
The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contains an ...
and
radixin
Radixin is a protein that in humans is encoded by the ''RDX'' gene.
Radixin is a cytoskeletal protein that may be important in linking actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoske ...
. ERM proteins appear to function as cross-linkers between
plasma membranes and
actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...
-based
cytoskeleton
The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. In eukaryotes, it extends from the cell nucleus to the cell membrane and is compos ...
s.
[
Moesin is localized to filopodia and other membranous protrusions that are important for cell–cell recognition and signaling and for cell movement.]
Interactions
Moesin has been shown to interact with:
* CD43[
* VCAM-1]
References
Further reading
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{{NLM content
Human proteins