Miriam (Mika) Salpeter (née Mark; April 8, 1929 – October 24, 2000) was an American academic. As professor of neurobiology at

Cornell University Cornell University is a Private university, private Ivy League research university based in Ithaca, New York, United States. The university was co-founded by American philanthropist Ezra Cornell and historian and educator Andrew Dickson W ...

, she developed quantitative electron microscopic

autoradiograph An autoradiograph is an image on an X-ray film or nuclear emulsion produced by the pattern of decay emissions (e.g., beta particles or gamma rays) from a distribution of a radioactive substance. Alternatively, the autoradiograph is also availab ...

y as a means to investigate the

neuromuscular junction A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. Muscles require innervation to ...

. The

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, D.C., for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well k ...

created the Mika Salpeter Lifetime Achievement Award in her honour.

Early life and education

Salpeter was born in

Riga Riga ( ) is the capital, Primate city, primate, and List of cities and towns in Latvia, largest city of Latvia. Home to 591,882 inhabitants (as of 2025), the city accounts for a third of Latvia's total population. The population of Riga Planni ...

. Her father was a

Yiddish Yiddish, historically Judeo-German, is a West Germanic language historically spoken by Ashkenazi Jews. It originated in 9th-century Central Europe, and provided the nascent Ashkenazi community with a vernacular based on High German fused with ...

scholar and Salpeter was fluent in

. During the rise of

Nazi Germany Nazi Germany, officially known as the German Reich and later the Greater German Reich, was the German Reich, German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a Totalit ...

Salpeter emigrated from

Latvia Latvia, officially the Republic of Latvia, is a country in the Baltic region of Northern Europe. It is one of the three Baltic states, along with Estonia to the north and Lithuania to the south. It borders Russia to the east and Belarus to t ...

Canada Canada is a country in North America. Its Provinces and territories of Canada, ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, making it the world's List of coun ...

, before moving to the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

in 1945. Salpeter attended high school in

New York City New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive w ...

. She was an undergraduate student at

Hunter College Hunter College is a public university in New York City, United States. It is one of the constituent colleges of the City University of New York and offers studies in more than one hundred undergraduate and postgraduate fields across five schools ...

, where she was a member of

Phi Beta Kappa The Phi Beta Kappa Society () is the oldest academic honor society in the United States. It was founded in 1776 at the College of William & Mary in Virginia. Phi Beta Kappa aims to promote and advocate excellence in the liberal arts and sciences, ...

and graduated ''

summa cum laude Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some Sout ...

''. Salpeter moved to

for her doctoral studies, where she earned a PhD under the supervision of Howard Liddell. She spent a year at the

Australian National University The Australian National University (ANU) is a public university, public research university and member of the Group of Eight (Australian universities), Group of Eight, located in Canberra, the capital of Australia. Its main campus in Acton, A ...

before returning to

as a postdoctoral fellow with Marcus Singer. Singer's laboratory was based in the Zoology department, where she studied cells using an

electron microscope An electron microscope is a microscope that uses a beam of electrons as a source of illumination. It uses electron optics that are analogous to the glass lenses of an optical light microscope to control the electron beam, for instance focusing it ...

. Salpeter was appointed a research associate in the Singer lab in 1961 and soon after promoted to Senior Research Associate.

Research and career

Neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...

was an emerging field at the start of Salpeter's research career, and she decided to concentrate her efforts on the

. The

is a synapse that controls all voluntary movement, the formation of which was extensively investigated by Salpeter throughout her research career. In particular, Salpeter looked at the role of

acetylcholine receptor An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Classification Like other transmembrane receptors, acetylcholine receptor ...

s. Salpeter struggled to secure a faculty position at

– Singer, her biggest advocate in the department, moved to

Case Western Reserve University Case Western Reserve University (CWRU) is a Private university, private research university in Cleveland, Ohio, United States. It was established in 1967 by a merger between Western Reserve University and the Case Institute of Technology. Case ...

, and the academic community were not welcoming to women. Salpeter did not let this atmosphere faze her, and continued her research as a non-faculty member. In 1967 Salpeter was recruited to the

Section of Neurobiology and Behavior. Here she worked in the laboratory of Benjamin Siegel and was supported by the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

. She spent a year in the laboratory of

Vincent Wigglesworth Sir Vincent Brian Wigglesworth CBE FRS (17 April 1899 – 11 February 1994) was a British entomologist who made significant contributions to the field of insect physiology. He established the field in a textbook which was updated in a number o ...

at the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

. In 1973 Salpeter was promoted to Professor. She developed quantitative electron microscopic

y, and demonstrated it as a sensitive means to study the

. Salpeter collaborated with her husband, astronomer and physicist

Edwin Ernest Salpeter Edwin Ernest Salpeter (3 December 1924 – 26 November 2008,) was an Austrian–Australian–American astrophysicist. Life Born in Vienna to a Jewish family, Salpeter emigrated from Austria to Australia while in his teens to escape the Nazis. H ...

, on the interactions between nerves and muscle fibres.

Awards and honours

The

created the Mika Salpeter Lifetime Achievement Award in her honour. Her awards and honours include: *

Patricia Goldman-Rakic Hall of Honor *Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsib ...

*Hall of Fame of the

City University of New York The City University of New York (CUNY, pronounced , ) is the Public university, public university system of Education in New York City, New York City. It is the largest urban university system in the United States, comprising 25 campuses: eleven ...

*Marcus Singer Award

Selected publications

* * *

Personal life

Salpeter married

in 1950. Together they had two daughters, Judy and Shelley. At the age of 71 she was diagnosed with

thyroid cancer Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck, ...

. She continued to visit her laboratory everyday until the day that she died.

References

{{DEFAULTSORT:Salpeter, Miriam Cornell University alumni Cornell University faculty 1929 births 2000 deaths Latvian emigrants to Canada American neuroscientists American women neuroscientists Canadian emigrants to the United States